Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4620132..4620789 Replicon chromosome
Accession NZ_CP063939
Organism Klebsiella pneumoniae strain BM343

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA62_RS22345 Protein ID WP_002916310.1
Coordinates 4620379..4620789 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA62_RS22340 Protein ID WP_002916312.1
Coordinates 4620132..4620398 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA62_RS22315 4615340..4616773 - 1434 WP_019704912.1 6-phospho-beta-glucosidase BglA -
ISA62_RS22320 4616892..4617620 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISA62_RS22325 4617670..4617981 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISA62_RS22330 4618145..4618804 + 660 WP_002916317.1 hemolysin III family protein -
ISA62_RS22335 4618903..4619886 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
ISA62_RS22340 4620132..4620398 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA62_RS22345 4620379..4620789 + 411 WP_002916310.1 protein YgfX Toxin
ISA62_RS22350 4620796..4621317 - 522 WP_004144730.1 flavodoxin FldB -
ISA62_RS22355 4621418..4622314 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA62_RS22360 4622337..4623050 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA62_RS22365 4623056..4624789 + 1734 WP_019704911.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179752 WP_002916310.1 NZ_CP063939:4620379-4620789 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179752 NZ_CP084893:c262893-262552 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179752 WP_002916312.1 NZ_CP063939:4620132-4620398 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179752 NZ_CP084893:c263231-262914 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References