Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2819139..2819655 Replicon chromosome
Accession NZ_CP063936
Organism Klebsiella pneumoniae strain BS317-1

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag ISA63_RS13785 Protein ID WP_009309309.1
Coordinates 2819371..2819655 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ISA63_RS13780 Protein ID WP_002886901.1
Coordinates 2819139..2819381 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA63_RS13765 2815167..2815907 + 741 WP_194445106.1 KDGP aldolase family protein -
ISA63_RS13770 2815974..2817128 + 1155 WP_004178372.1 lactonase family protein -
ISA63_RS13775 2817151..2819061 + 1911 WP_009486549.1 BglG family transcription antiterminator -
ISA63_RS13780 2819139..2819381 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISA63_RS13785 2819371..2819655 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA63_RS13790 2819659..2820123 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISA63_RS13795 2820452..2822501 - 2050 Protein_2673 anaerobic ribonucleoside-triphosphate reductase -
ISA63_RS13800 2822858..2823529 - 672 WP_194445107.1 MurR/RpiR family transcriptional regulator -
ISA63_RS13805 2823532..2823705 - 174 WP_040248667.1 hypothetical protein -
ISA63_RS13810 2823790..2824098 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T179729 WP_009309309.1 NZ_CP063936:2819371-2819655 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T179729 NZ_CP084879:c2010476-2010369 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTGCCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179729 WP_002886901.1 NZ_CP063936:2819139-2819381 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179729 NZ_CP084879:2010523-2010589 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References