Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1599282..1599964 Replicon chromosome
Accession NZ_CP063936
Organism Klebsiella pneumoniae strain BS317-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag ISA63_RS07815 Protein ID WP_047666954.1
Coordinates 1599282..1599623 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag ISA63_RS07820 Protein ID WP_047666955.1
Coordinates 1599644..1599964 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA63_RS07795 1594509..1596254 + 1746 WP_004149864.1 DNA primase -
ISA63_RS07800 1596473..1598314 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
ISA63_RS07805 1598414..1598920 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
ISA63_RS07815 1599282..1599623 - 342 WP_047666954.1 TA system toxin CbtA family protein Toxin
ISA63_RS07820 1599644..1599964 - 321 WP_047666955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ISA63_RS07825 1599986..1600207 - 222 WP_016151535.1 DUF987 domain-containing protein -
ISA63_RS07830 1600216..1600698 - 483 WP_047666956.1 RadC family protein -
ISA63_RS07835 1600707..1601150 - 444 WP_047666957.1 antirestriction protein -
ISA63_RS07840 1601181..1602002 - 822 WP_047666958.1 DUF945 domain-containing protein -
ISA63_RS07845 1602101..1602331 - 231 WP_047666960.1 DUF905 domain-containing protein -
ISA63_RS07850 1602403..1602852 - 450 WP_169546675.1 hypothetical protein -
ISA63_RS07855 1602849..1603301 - 453 WP_015699705.1 hypothetical protein -
ISA63_RS07860 1603338..1603907 - 570 WP_047666965.1 hypothetical protein -
ISA63_RS07865 1603907..1604611 - 705 WP_047666967.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1599282..1615746 16464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12888.95 Da        Isoelectric Point: 9.6542

>T179726 WP_047666954.1 NZ_CP063936:c1599623-1599282 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRARQAIGLLRRSRNNAVL

Download         Length: 342 bp

>T179726 NZ_CP084879:c1117962-1117804 [Shigella flexneri]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12049.53 Da        Isoelectric Point: 6.6255

>AT179726 WP_047666955.1 NZ_CP063936:c1599964-1599644 [Klebsiella pneumoniae]
MSSNVTWGLQRDNTPRLGARLVQEGNRLHYLADRASITGKLSDAECRRLDETFPHFISQMESMLTTDELNPRHAHCVTLY
HNGFTCEAETLGSCGYVYIAIYPTQR

Download         Length: 321 bp

>AT179726 NZ_CP084879:c1118257-1117946 [Shigella flexneri]
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References