Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3537538..3539126 Replicon chromosome
Accession NZ_CP063934
Organism Klebsiella pneumoniae strain BS326-3

Toxin (Protein)


Gene name hipA Uniprot ID A0A486JB51
Locus tag ISA64_RS17135 Protein ID WP_023316847.1
Coordinates 3537538..3538860 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag ISA64_RS17140 Protein ID WP_002904790.1
Coordinates 3538860..3539126 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA64_RS17120 3532594..3535095 + 2502 WP_032412215.1 fimbrial biogenesis outer membrane usher protein -
ISA64_RS17125 3535083..3536087 + 1005 WP_032412210.1 type 1 fimbrial protein -
ISA64_RS17130 3536229..3537521 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
ISA64_RS17135 3537538..3538860 - 1323 WP_023316847.1 type II toxin-antitoxin system HipA family toxin Toxin
ISA64_RS17140 3538860..3539126 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ISA64_RS17145 3539391..3539717 - 327 WP_002904788.1 hydroxyisourate hydrolase -
ISA64_RS17150 3539714..3540214 - 501 WP_032412207.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ISA64_RS17155 3540192..3541571 - 1380 WP_032412205.1 purine permease -
ISA64_RS17160 3541917..3543071 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
ISA64_RS17165 3543052..3543975 - 924 WP_023297602.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T179713 WP_023316847.1 NZ_CP063934:c3538860-3537538 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T179713 NZ_CP084876:1903257-1903359 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT179713 WP_002904790.1 NZ_CP063934:c3539126-3538860 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT179713 NZ_CP084876:c1903363-1903216 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486JB51

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References