Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1684383..1685040 Replicon chromosome
Accession NZ_CP063934
Organism Klebsiella pneumoniae strain BS326-3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA64_RS08150 Protein ID WP_002916310.1
Coordinates 1684630..1685040 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA64_RS08145 Protein ID WP_002916312.1
Coordinates 1684383..1684649 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA64_RS08120 1679539..1680972 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
ISA64_RS08125 1681091..1681819 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISA64_RS08130 1681869..1682180 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISA64_RS08135 1682344..1683003 + 660 WP_002916317.1 hemolysin III family protein -
ISA64_RS08140 1683154..1684137 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ISA64_RS08145 1684383..1684649 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA64_RS08150 1684630..1685040 + 411 WP_002916310.1 protein YgfX Toxin
ISA64_RS08155 1685047..1685568 - 522 WP_004144730.1 flavodoxin FldB -
ISA64_RS08160 1685669..1686565 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA64_RS08165 1686588..1687301 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA64_RS08170 1687307..1689040 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179702 WP_002916310.1 NZ_CP063934:1684630-1685040 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179702 NZ_CP084874:1780368-1780700 [Klebsiella africana]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179702 WP_002916312.1 NZ_CP063934:1684383-1684649 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179702 NZ_CP084874:1780110-1780367 [Klebsiella africana]
ATGTATACAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References