Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 348586..349102 Replicon chromosome
Accession NZ_CP063934
Organism Klebsiella pneumoniae strain BS326-3

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag ISA64_RS01630 Protein ID WP_009309309.1
Coordinates 348586..348870 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ISA64_RS01635 Protein ID WP_002886901.1
Coordinates 348860..349102 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA64_RS01605 344062..344370 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
ISA64_RS01610 344455..344628 + 174 WP_032408826.1 hypothetical protein -
ISA64_RS01615 344631..345374 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ISA64_RS01620 345731..347869 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
ISA64_RS01625 348118..348582 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISA64_RS01630 348586..348870 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA64_RS01635 348860..349102 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISA64_RS01640 349180..351090 - 1911 WP_009486549.1 BglG family transcription antiterminator -
ISA64_RS01645 351113..352267 - 1155 WP_194429444.1 lactonase family protein -
ISA64_RS01650 352334..353074 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T179697 WP_009309309.1 NZ_CP063934:c348870-348586 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T179697 NZ_CP084873:c5079950-5079567 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCAGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179697 WP_002886901.1 NZ_CP063934:c349102-348860 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179697 NZ_CP084873:c5080192-5079950 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References