Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 3404884..3405541 | Replicon | chromosome |
Accession | NZ_CP063930 | ||
Organism | Klebsiella pneumoniae strain M186-2 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | W8UCT0 |
Locus tag | ISA67_RS16345 | Protein ID | WP_002916310.1 |
Coordinates | 3405131..3405541 (+) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | ISA67_RS16340 | Protein ID | WP_002916312.1 |
Coordinates | 3404884..3405150 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ISA67_RS16315 | 3400092..3401525 | - | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
ISA67_RS16320 | 3401644..3402372 | - | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
ISA67_RS16325 | 3402422..3402733 | + | 312 | WP_002916319.1 | N(4)-acetylcytidine aminohydrolase | - |
ISA67_RS16330 | 3402897..3403556 | + | 660 | WP_002916317.1 | hemolysin III family protein | - |
ISA67_RS16335 | 3403655..3404638 | - | 984 | WP_101816992.1 | tRNA-modifying protein YgfZ | - |
ISA67_RS16340 | 3404884..3405150 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
ISA67_RS16345 | 3405131..3405541 | + | 411 | WP_002916310.1 | protein YgfX | Toxin |
ISA67_RS16350 | 3405548..3406069 | - | 522 | WP_002916308.1 | flavodoxin FldB | - |
ISA67_RS16355 | 3406170..3407066 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
ISA67_RS16360 | 3407089..3407802 | + | 714 | WP_002916301.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
ISA67_RS16365 | 3407808..3409541 | + | 1734 | WP_023286863.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16049.85 Da Isoelectric Point: 11.4778
>T179643 WP_002916310.1 NZ_CP063930:3405131-3405541 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T179643 NZ_CP084866:2058039-2058141 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT179643 WP_002916312.1 NZ_CP063930:3404884-3405150 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT179643 NZ_CP084866:c2058148-2058003 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GSW7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |