Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3404884..3405541 Replicon chromosome
Accession NZ_CP063930
Organism Klebsiella pneumoniae strain M186-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA67_RS16345 Protein ID WP_002916310.1
Coordinates 3405131..3405541 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA67_RS16340 Protein ID WP_002916312.1
Coordinates 3404884..3405150 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA67_RS16315 3400092..3401525 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
ISA67_RS16320 3401644..3402372 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISA67_RS16325 3402422..3402733 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
ISA67_RS16330 3402897..3403556 + 660 WP_002916317.1 hemolysin III family protein -
ISA67_RS16335 3403655..3404638 - 984 WP_101816992.1 tRNA-modifying protein YgfZ -
ISA67_RS16340 3404884..3405150 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA67_RS16345 3405131..3405541 + 411 WP_002916310.1 protein YgfX Toxin
ISA67_RS16350 3405548..3406069 - 522 WP_002916308.1 flavodoxin FldB -
ISA67_RS16355 3406170..3407066 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA67_RS16360 3407089..3407802 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA67_RS16365 3407808..3409541 + 1734 WP_023286863.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179643 WP_002916310.1 NZ_CP063930:3405131-3405541 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179643 NZ_CP084866:2058039-2058141 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179643 WP_002916312.1 NZ_CP063930:3404884-3405150 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179643 NZ_CP084866:c2058148-2058003 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References