Detailed information of TA system TA179640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2219180..2220861
• Replicon: chromosome
• Accession: NZ_CP063930
• Organism: Klebsiella pneumoniae strain M186-2

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486RE08
• Locus tag: ISA67_RS10580
• Protein ID: WP_023287018.1
• Coordinates: 2219180..2220097 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A486RD25
• Locus tag: ISA67_RS10585
• Protein ID: WP_023287017.1
• Coordinates: 2220103..2220861 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA67_RS10560	2214486..2216006	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
ISA67_RS10565	2216003..2217001	+	999	WP_002885172.1	ribose ABC transporter permease	-
ISA67_RS10570	2217032..2217973	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
ISA67_RS10575	2218048..2219055	+	1008	WP_023287019.1	carbohydrate kinase family protein	-
ISA67_RS10580	2219180..2220097	-	918	WP_023287018.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ISA67_RS10585	2220103..2220861	-	759	WP_023287017.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ISA67_RS10590	2220947..2221675	-	729	WP_004177810.1	response regulator transcription factor	-
ISA67_RS10595	2221948..2224095	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
ISA67_RS10600	2224325..2225011	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34587.04 Da
• Isoelectric Point: 5.7772

>T179640 WP_023287018.1 NZ_CP063930:c2220097-2219180 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIGVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T179640 NZ_CP084866:325442-325810 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28534.90 Da
• Isoelectric Point: 10.0870

>AT179640 WP_023287017.1 NZ_CP063930:c2220861-2220103 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVVSGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT179640 NZ_CP084866:325224-325445 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A486RE08

Antitoxin

• AlphaFold DB: A0A486RD25