Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4062405..4063062 Replicon chromosome
Accession NZ_CP063927
Organism Klebsiella pneumoniae strain S183-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA68_RS19685 Protein ID WP_002916310.1
Coordinates 4062652..4063062 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA68_RS19680 Protein ID WP_002916312.1
Coordinates 4062405..4062671 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA68_RS19655 4057561..4058994 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
ISA68_RS19660 4059113..4059841 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISA68_RS19665 4059891..4060202 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
ISA68_RS19670 4060366..4061025 + 660 WP_002916317.1 hemolysin III family protein -
ISA68_RS19675 4061176..4062159 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ISA68_RS19680 4062405..4062671 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA68_RS19685 4062652..4063062 + 411 WP_002916310.1 protein YgfX Toxin
ISA68_RS19690 4063069..4063590 - 522 WP_004144730.1 flavodoxin FldB -
ISA68_RS19695 4063691..4064587 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA68_RS19700 4064610..4065323 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA68_RS19705 4065329..4067062 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179607 WP_002916310.1 NZ_CP063927:4062652-4063062 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179607 NZ_CP084856:4047360-4047578 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179607 WP_002916312.1 NZ_CP063927:4062405-4062671 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179607 NZ_CP084856:4046959-4047333 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References