Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4555445..4556102 Replicon chromosome
Accession NZ_CP063926
Organism Klebsiella variicola strain S187-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA69_RS21890 Protein ID WP_002916310.1
Coordinates 4555692..4556102 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA69_RS21885 Protein ID WP_002916312.1
Coordinates 4555445..4555711 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA69_RS21860 4550594..4552027 - 1434 WP_032736405.1 6-phospho-beta-glucosidase BglA -
ISA69_RS21865 4552147..4552875 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
ISA69_RS21870 4552926..4553237 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
ISA69_RS21875 4553401..4554060 + 660 WP_008806429.1 hemolysin III family protein -
ISA69_RS21880 4554216..4555199 - 984 WP_008806428.1 tRNA-modifying protein YgfZ -
ISA69_RS21885 4555445..4555711 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA69_RS21890 4555692..4556102 + 411 WP_002916310.1 protein YgfX Toxin
ISA69_RS21895 4556109..4556630 - 522 WP_008806427.1 flavodoxin FldB -
ISA69_RS21900 4556731..4557627 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
ISA69_RS21905 4557650..4558363 + 714 WP_032736403.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA69_RS21910 4558369..4560102 + 1734 WP_012540594.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179597 WP_002916310.1 NZ_CP063926:4555692-4556102 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179597 NZ_CP084852:c4677816-4677283 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179597 WP_002916312.1 NZ_CP063926:4555445-4555711 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179597 NZ_CP084852:c4678093-4677827 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References