Detailed information of TA system TA179593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3361511..3363192
• Replicon: chromosome
• Accession: NZ_CP063926
• Organism: Klebsiella variicola strain S187-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: ISA69_RS16120
• Protein ID: WP_022065798.1
• Coordinates: 3361511..3362428 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A0B7GCX3
• Locus tag: ISA69_RS16125
• Protein ID: WP_008807257.1
• Coordinates: 3362434..3363192 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA69_RS16100	3356817..3358337	+	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-
ISA69_RS16105	3358334..3359332	+	999	WP_023296904.1	ribose ABC transporter permease	-
ISA69_RS16110	3359363..3360304	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
ISA69_RS16115	3360379..3361386	+	1008	WP_012969142.1	carbohydrate kinase family protein	-
ISA69_RS16120	3361511..3362428	-	918	WP_022065798.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ISA69_RS16125	3362434..3363192	-	759	WP_008807257.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ISA69_RS16130	3363277..3364005	-	729	WP_008807258.1	response regulator transcription factor	-
ISA69_RS16135	3364278..3366425	+	2148	WP_077625434.1	formate dehydrogenase subunit alpha	-
ISA69_RS16140	3367043..3367729	+	687	WP_008807260.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34751.14 Da
• Isoelectric Point: 5.4707

>T179593 WP_022065798.1 NZ_CP063926:c3362428-3361511 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T179593 NZ_CP084852:2033005-2033107 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28653.01 Da
• Isoelectric Point: 10.1988

>AT179593 WP_008807257.1 NZ_CP063926:c3363192-3362434 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT179593 NZ_CP084852:c2033114-2032969 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Antitoxin

• AlphaFold DB: A0A0B7GCX3