Detailed information of TA system TA179540

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 400363..401951
• Replicon: chromosome
• Accession: NZ_CP063922
• Organism: Klebsiella pneumoniae strain BM338-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9J6RYF8
• Locus tag: ISA71_RS02050
• Protein ID: WP_004892016.1
• Coordinates: 400629..401951 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: ISA71_RS02045
• Protein ID: WP_004176198.1
• Coordinates: 400363..400629 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA71_RS02020	395514..396437	+	924	WP_004892028.1	LysR family hpxDE operon transcriptional regulator HpxR	-
ISA71_RS02025	396418..397572	-	1155	WP_004892025.1	FAD-dependent urate hydroxylase HpxO	-
ISA71_RS02030	397918..399297	+	1380	WP_004176204.1	purine permease	-
ISA71_RS02035	399275..399775	+	501	WP_004892023.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
ISA71_RS02040	399772..400098	+	327	WP_004892019.1	hydroxyisourate hydrolase	-
ISA71_RS02045	400363..400629	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
ISA71_RS02050	400629..401951	+	1323	WP_004892016.1	type II toxin-antitoxin system HipA family toxin	Toxin
ISA71_RS02055	401968..403260	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
ISA71_RS02060	403402..404406	-	1005	WP_004892012.1	type 1 fimbrial protein	-
ISA71_RS02065	404394..406895	-	2502	WP_004892009.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	iroE / mgtC	364880..593796	228916

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T179540 WP_004892016.1 NZ_CP063922:400629-401951 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T179540 NZ_CP084825:716094-716579 [Klebsiella pneumoniae]
ATGATCTCCGCTCCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTATGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT179540 WP_004176198.1 NZ_CP063922:400363-400629 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT179540 NZ_CP084825:715804-716097 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGTATGACGATGAAACGCGAAACCTTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGAGCTGCCGCTGAGGAAGCGTTGA
TTGAGCAACGCATTATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTGGCCCGTCTGGATCAGGCTCCTGAGCCCAAT
GCCGCATTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA