Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4814189..4814831 Replicon chromosome
Accession NZ_CP063919
Organism Klebsiella pneumoniae strain BM337-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ISA74_RS23410 Protein ID WP_075647414.1
Coordinates 4814658..4814831 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ISA74_RS23405 Protein ID WP_075647415.1
Coordinates 4814189..4814599 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA74_RS23365 4809401..4809835 - 435 WP_012542168.1 phage terminase small subunit P27 family -
ISA74_RS23370 4810085..4810516 - 432 WP_081277328.1 hypothetical protein -
ISA74_RS23375 4810513..4810836 - 324 WP_194429326.1 hypothetical protein -
ISA74_RS23380 4810788..4811150 - 363 WP_017880264.1 HNH endonuclease -
ISA74_RS23385 4811134..4811340 - 207 WP_023159883.1 hypothetical protein -
ISA74_RS23390 4812284..4812634 - 351 WP_016160650.1 hypothetical protein -
ISA74_RS23395 4812631..4813128 - 498 WP_075647416.1 lysozyme -
ISA74_RS23400 4813128..4813343 - 216 WP_017880269.1 class II holin family protein -
ISA74_RS23405 4814189..4814599 - 411 WP_075647415.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISA74_RS23410 4814658..4814831 - 174 WP_075647414.1 type II toxin-antitoxin system HicA family toxin Toxin
ISA74_RS23415 4815097..4815960 + 864 WP_075647413.1 hypothetical protein -
ISA74_RS23420 4816223..4816639 + 417 WP_130943902.1 hypothetical protein -
ISA74_RS23425 4816655..4817020 - 366 WP_075647411.1 DUF1133 family protein -
ISA74_RS23430 4817039..4818019 - 981 WP_075647410.1 DUF968 domain-containing protein -
ISA74_RS23435 4818044..4818853 - 810 WP_075647409.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
ISA74_RS23440 4818850..4819764 - 915 WP_040188691.1 conserved phage C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4780797..4824830 44033


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(86-128)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6603.75 Da        Isoelectric Point: 11.3260

>T179520 WP_075647414.1 NZ_CP063919:c4814831-4814658 [Klebsiella pneumoniae]
VKQREFQRWLESQGVEITDGAKHLKLRLNGKRSVMPRHPGSEIVEQLRKAILKQLGL

Download         Length: 174 bp

>T179520 NZ_CP084818:c4695602-4695234 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCGAAATCTGGCAAAAATTACTGGAGTATCT
GCTGGAGCAACACTACGGCCTTACCCTCAACGACACGCCGTTTGGCAACGACAGTGTGATCCAGAAACACATTGATGCGG
GAATCTCACTGTGTGACGCGGTGAATTCTATCGTGGAAAAGTACGACCTGGTACGTACTGACCGTCACGGTTTCAGCGTG
AAAGAGCAGTCTCCGTTTATCGGCAGCATTGATATGCTCCGCGCCCGCAAGGCTACCAGGCTGATGCCCCGCAAGGGCTA
TCAAACCGTTACTGACATTACCAGTGGCAGATCCAGCGAAGGGAAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15269.40 Da        Isoelectric Point: 4.4249

>AT179520 WP_075647415.1 NZ_CP063919:c4814599-4814189 [Klebsiella pneumoniae]
MRYPVNLSKAEEGGFFVEFPDIPEALTQGDTKEEALDNALDALVTAFEFYFEDGDRIPEPGVPTGDYVELPLSIEAKVLM
LNAFIESKLSQTELAAKMNVKKQEVTRLFDLKHSTKIDTIQKAVNSLGHRMELKYA

Download         Length: 411 bp

>AT179520 NZ_CP084818:c4696017-4695658 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGCAGAAAACAACCAGTGTCATCAACCATAACATCGCGGAGCCCTGGTGGGGCCTCAAACGCAACATCACGCCGTGTTT
TGGTGCACGGCTGGTACAGGAGGGTAATCACCTGCATTACCTTGCTGACCGCGCCAACATTACCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGGTACTGATGAAGCAGATGGAGCTCATGCTGACCAGCAACGAACTCACG
CCCCACATTCAGCGCTGCATCACGCTCCACGCAAAAGGGCTGATATGTGAGGCCGATACGCTCGGCTCCTGTGGCTATTT
GTATATCGTAATTTATCCGACATCTGCAATAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References