Detailed information of TA system TA179506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1719591..1721272
• Replicon: chromosome
• Accession: NZ_CP063919
• Organism: Klebsiella pneumoniae strain BM337-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: ISA74_RS08275
• Protein ID: WP_015959269.1
• Coordinates: 1720397..1721272 (+)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: ISA74_RS08270
• Protein ID: WP_004177809.1
• Coordinates: 1719591..1720349 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA74_RS08255	1715441..1716127	-	687	WP_032413196.1	sel1 repeat family protein	-
ISA74_RS08260	1716357..1718504	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
ISA74_RS08265	1718777..1719505	+	729	WP_002885152.1	response regulator transcription factor	-
ISA74_RS08270	1719591..1720349	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ISA74_RS08275	1720397..1721272	+	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ISA74_RS08280	1721397..1722404	-	1008	WP_015959270.1	carbohydrate kinase family protein	-
ISA74_RS08285	1722479..1723420	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
ISA74_RS08290	1723451..1724449	-	999	WP_002885172.1	ribose ABC transporter permease	-
ISA74_RS08295	1724446..1725966	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T179506 WP_015959269.1 NZ_CP063919:1720397-1721272 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T179506 NZ_CP084806:1881004-1881106 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT179506 WP_004177809.1 NZ_CP063919:1719591-1720349 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT179506 NZ_CP084806:c1881112-1880968 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05