Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4721690..4722347 Replicon chromosome
Accession NZ_CP063915
Organism Klebsiella variicola strain M186-1-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA77_RS22630 Protein ID WP_002916310.1
Coordinates 4721690..4722100 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA77_RS22635 Protein ID WP_002916312.1
Coordinates 4722081..4722347 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA77_RS22610 4717690..4719423 - 1734 WP_012540594.1 single-stranded-DNA-specific exonuclease RecJ -
ISA77_RS22615 4719429..4720142 - 714 WP_032736403.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA77_RS22620 4720165..4721061 - 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
ISA77_RS22625 4721162..4721683 + 522 WP_008806427.1 flavodoxin FldB -
ISA77_RS22630 4721690..4722100 - 411 WP_002916310.1 protein YgfX Toxin
ISA77_RS22635 4722081..4722347 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA77_RS22640 4722593..4723576 + 984 WP_008806428.1 tRNA-modifying protein YgfZ -
ISA77_RS22645 4723732..4724391 - 660 WP_008806429.1 hemolysin III family protein -
ISA77_RS22650 4724555..4724866 - 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
ISA77_RS22655 4724917..4725645 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
ISA77_RS22660 4725765..4727198 + 1434 WP_032736405.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179464 WP_002916310.1 NZ_CP063915:c4722100-4721690 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179464 NZ_CP084770:833969-834379 [Klebsiella quasipneumoniae subsp. similipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179464 WP_002916312.1 NZ_CP063915:c4722347-4722081 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179464 NZ_CP084770:833722-833988 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References