Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2953294..2953951 Replicon chromosome
Accession NZ_CP063913
Organism Klebsiella pneumoniae strain BM336-2-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA78_RS14065 Protein ID WP_002916310.1
Coordinates 2953541..2953951 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA78_RS14060 Protein ID WP_002916312.1
Coordinates 2953294..2953560 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA78_RS14035 2948450..2949883 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
ISA78_RS14040 2950002..2950730 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISA78_RS14045 2950780..2951091 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISA78_RS14050 2951255..2951914 + 660 WP_002916317.1 hemolysin III family protein -
ISA78_RS14055 2952065..2953048 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ISA78_RS14060 2953294..2953560 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA78_RS14065 2953541..2953951 + 411 WP_002916310.1 protein YgfX Toxin
ISA78_RS14070 2953958..2954479 - 522 WP_002916308.1 flavodoxin FldB -
ISA78_RS14075 2954580..2955476 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA78_RS14080 2955499..2956212 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA78_RS14085 2956218..2957951 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179438 WP_002916310.1 NZ_CP063913:2953541-2953951 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179438 NZ_CP084765:c4086249-4085932 [Klebsiella variicola subsp. variicola]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGTTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCTCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179438 WP_002916312.1 NZ_CP063913:2953294-2953560 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179438 NZ_CP084765:c4085939-4085652 [Klebsiella variicola subsp. variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References