Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2001526..2002183 Replicon chromosome
Accession NZ_CP063911
Organism Klebsiella variicola strain M186-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA80_RS09765 Protein ID WP_002916310.1
Coordinates 2001526..2001936 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA80_RS09770 Protein ID WP_002916312.1
Coordinates 2001917..2002183 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA80_RS09745 1997526..1999259 - 1734 WP_012540594.1 single-stranded-DNA-specific exonuclease RecJ -
ISA80_RS09750 1999265..1999978 - 714 WP_032736403.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA80_RS09755 2000001..2000897 - 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
ISA80_RS09760 2000998..2001519 + 522 WP_008806427.1 flavodoxin FldB -
ISA80_RS09765 2001526..2001936 - 411 WP_002916310.1 protein YgfX Toxin
ISA80_RS09770 2001917..2002183 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA80_RS09775 2002429..2003412 + 984 WP_008806428.1 tRNA-modifying protein YgfZ -
ISA80_RS09780 2003568..2004227 - 660 WP_008806429.1 hemolysin III family protein -
ISA80_RS09785 2004391..2004702 - 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
ISA80_RS09790 2004753..2005481 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
ISA80_RS09795 2005601..2007034 + 1434 WP_032736405.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179405 WP_002916310.1 NZ_CP063911:c2001936-2001526 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179405 NZ_CP084741:c511862-511608 [Pectobacterium carotovorum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGTATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAAGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTTGCTG
GTTTCTGGTCGCGCCGCATCACCGAAGAACACCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179405 WP_002916312.1 NZ_CP063911:c2002183-2001917 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179405 NZ_CP084741:c512110-511859 [Pectobacterium carotovorum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTCATGTCTTTGGAAGAGTATAACTCTCTAGAGGAGACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References