Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 75548..76458 Replicon plasmid pM212-2
Accession NZ_CP063909
Organism Klebsiella pneumoniae strain M212-2

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag ISA82_RS26405 Protein ID WP_004026354.1
Coordinates 75548..76018 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag ISA82_RS26410 Protein ID WP_004026357.1
Coordinates 76015..76458 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA82_RS26385 70960..71358 - 399 WP_004212796.1 H-NS histone family protein -
ISA82_RS26390 71695..72189 - 495 WP_004212794.1 thermonuclease family protein -
ISA82_RS26395 72367..73316 + 950 Protein_79 DUF1173 family protein -
ISA82_RS26400 74702..75399 - 698 Protein_80 IS1 family transposase -
ISA82_RS26405 75548..76018 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
ISA82_RS26410 76015..76458 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
ISA82_RS26415 76559..77062 - 504 Protein_83 DUF4113 domain-containing protein -
ISA82_RS26420 77160..77381 - 222 WP_004213643.1 DUF2188 domain-containing protein -
ISA82_RS26425 77526..77681 - 156 WP_004213642.1 hypothetical protein -
ISA82_RS26430 77756..79882 - 2127 WP_004213640.1 TonB-dependent receptor family protein -
ISA82_RS26435 79969..80922 - 954 Protein_87 fec operon regulator FecR -
ISA82_RS26440 80919..81440 - 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA 1..214844 214844
- flank IS/Tn - - 74702..75205 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T179376 WP_004026354.1 NZ_CP063909:c76018-75548 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T179376 NZ_CP084722:2762-3049 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT179376 WP_004026357.1 NZ_CP063909:c76458-76015 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT179376 NZ_CP084722:3036-3350 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References