Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4700153..4700669 Replicon chromosome
Accession NZ_CP063908
Organism Klebsiella pneumoniae strain M212-2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag ISA82_RS22640 Protein ID WP_004178374.1
Coordinates 4700385..4700669 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ISA82_RS22635 Protein ID WP_002886901.1
Coordinates 4700153..4700395 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA82_RS22620 4696181..4696921 + 741 WP_002886899.1 KDGP aldolase family protein -
ISA82_RS22625 4696988..4698142 + 1155 WP_012737230.1 lactonase family protein -
ISA82_RS22630 4698165..4700075 + 1911 WP_094966167.1 BglG family transcription antiterminator -
ISA82_RS22635 4700153..4700395 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISA82_RS22640 4700385..4700669 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA82_RS22645 4700673..4701137 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISA82_RS22650 4701466..4703604 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
ISA82_RS22655 4703961..4704704 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ISA82_RS22660 4704707..4704880 - 174 WP_041169004.1 hypothetical protein -
ISA82_RS22665 4704965..4705273 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T179373 WP_004178374.1 NZ_CP063908:4700385-4700669 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T179373 NZ_CP084719:738554-738907 [Staphylococcus chromogenes]
ATGAAGCGTGGCGATGTTTATTTAGCGGATTTATCACCAGTACAAGGGTCAGAGCAAGGGGGAGTCAGACCTGTCGTTAT
TATTCAAAATGATACTGGTAATAAATACAGTCCGACCGTGATTGTTGCAGCGATTACAGGTCGCATCAATAAAGCGAAAA
TTCCAACGCATGTCGAAATTGATAAGAAAAAATATAAACTCGACAAAGATTCTGTTATTTTGTTAGAACAAATTAGAACA
GTCGATAAAAAGAGGCTTAAAGAAAAGCTTACCTTTCTTTCTGATAAAAAGATGAAAGAGGTCAATGCGGCACTTGGAAT
TAGCTTAGGATTGCACATGAATCAACACAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179373 WP_002886901.1 NZ_CP063908:4700153-4700395 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179373 NZ_CP084719:738383-738553 [Staphylococcus chromogenes]
ATGTCAGCATTCAATCAAACAAGAGTGAAAAGTTTAGAGCAATCTTTGAAAGAGGGGTATGTTCAGATGGCAGATTTAAA
TCTCTCCCTAGCAACAGAAGCATACTTTGTCGAATGTGAAGCATGTGATTGCAACGAATCACACTTACTTTCTAACCACA
AGGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References