Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3354623..3355280 Replicon chromosome
Accession NZ_CP063908
Organism Klebsiella pneumoniae strain M212-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA82_RS16080 Protein ID WP_002916310.1
Coordinates 3354623..3355033 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA82_RS16085 Protein ID WP_002916312.1
Coordinates 3355014..3355280 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA82_RS16060 3350623..3352356 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
ISA82_RS16065 3352362..3353075 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA82_RS16070 3353098..3353994 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA82_RS16075 3354095..3354616 + 522 WP_002916308.1 flavodoxin FldB -
ISA82_RS16080 3354623..3355033 - 411 WP_002916310.1 protein YgfX Toxin
ISA82_RS16085 3355014..3355280 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA82_RS16090 3355526..3356509 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
ISA82_RS16095 3356608..3357267 - 660 WP_002916317.1 hemolysin III family protein -
ISA82_RS16100 3357431..3357742 - 312 WP_165709834.1 N(4)-acetylcytidine aminohydrolase -
ISA82_RS16105 3357792..3358520 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISA82_RS16110 3358639..3360072 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179369 WP_002916310.1 NZ_CP063908:c3355033-3354623 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179369 NZ_CP084713:5365431-5365859 [Mycolicibacterium phocaicum]
ATGCTCCTCGTTGACGTCAACATCTGGGTCTATGCCATCCGCAGCGACAGCGCCCAGCACGGCACCTATCGAGAATGGGT
CGAAGAAGCGCTCACCGGCTCCGAACCAGTAGGCGTCAGCGAATTGGTGCTTTCCGGCGTCATGCGACTGATCACCAACC
ACCGGATTTTCTCGCAACCAAGCTCGACGGCAGAAGCTCTCGACGCATGCCGCGCGATCCGCTCAGCACCGTCGGCGATA
TCGCTACGGCCCGGACCCCGCCATTGGTCAATATTCGAAAAACTGTGCACGACCGTCGGCGCCAAGGCCAACGTCGTCCC
GGATGCCTACCACGCGGCGCTCGCGATCGAACACGGCGCCACATGGGTCACCACGGACCGGGCCTTCGCCCGCTTTCCAG
GTCTGAAGTGGCGCCTACCTTTTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179369 WP_002916312.1 NZ_CP063908:c3355280-3355014 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179369 NZ_CP084713:5365196-5365444 [Mycolicibacterium phocaicum]
ATGCGCACCACCGTCAACATCGACGATCACCTACTGGAAGAGGCCAAGGTGCTCGCGGCCAGGACATCCCGAAGCCTGGG
CTCGGTGGTCGAGGACGGACTTCGGGCATTGCTGCACCGAAACAACCCCGGCACGAGCGTCGGCACATTCGTGCTTCCAA
CCCACGGGATCGGCGGCCTTGCCCCCGGGGTCGATCTGGAAGACAAAGACGCCCTCGCCGAACTGACCGGCGACAATGCT
CCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References