Detailed information of TA system TA179360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1409786..1411374
• Replicon: chromosome
• Accession: NZ_CP063908
• Organism: Klebsiella pneumoniae strain M212-2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A331XLA5
• Locus tag: ISA82_RS06730
• Protein ID: WP_014907613.1
• Coordinates: 1410052..1411374 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: ISA82_RS06725
• Protein ID: WP_002904790.1
• Coordinates: 1409786..1410052 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA82_RS06700	1404964..1405887	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
ISA82_RS06705	1405868..1407022	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
ISA82_RS06710	1407368..1408747	+	1380	WP_094966147.1	purine permease	-
ISA82_RS06715	1408725..1409225	+	501	WP_004184022.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
ISA82_RS06720	1409222..1409548	+	327	WP_004215084.1	hydroxyisourate hydrolase	-
ISA82_RS06725	1409786..1410052	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
ISA82_RS06730	1410052..1411374	+	1323	WP_014907613.1	type II toxin-antitoxin system HipA family toxin	Toxin
ISA82_RS06735	1411391..1412683	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
ISA82_RS06740	1412825..1413829	-	1005	WP_014907612.1	type 1 fimbrial protein	-
ISA82_RS06745	1413817..1416318	-	2502	WP_014907611.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T179360 WP_014907613.1 NZ_CP063908:1410052-1411374 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T179360 NZ_CP084713:703585-704022 [Mycolicibacterium phocaicum]
ATGGCAAAGCTCTCAAGTTCCATCGAAGTACCGCTGTCGCCCGAAAAGGCCTGGGAGGCAGCGTCGGACCTCTCCCGGTA
CGACGACTGGCTGTCCATCCACCGGATGTGGCGCAGCCCGTTGCCCGAGACCCTGGGGAAGGGCACGCAGATCTCGTCCG
TCGTCGAGGTCAAGGGCATGCTGAACCGGGTCGACTGGACCATCGTGCACTACAACCCGCCGGGATCGTTGACCCTCAAC
GGCGTCGGCAAGGGTGGGGTCCGGGTCAAGTTGATGGCCAAGATCACGCCGGCCGGCGACGGTTCGAACGTGGCGTTCGA
CATCCACCTCGGTGGCCCGGCCCTGTTCGGACCCATCGGCATGGTGGTGGCGGCCGCACTGCGGTCCGACATCCACCAGT
CACTGGAGAAGTTCAAGGCGCTGTTCGCGTCGGTGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT179360 WP_002904790.1 NZ_CP063908:1409786-1410052 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT179360 NZ_CP084713:703361-703582 [Mycolicibacterium phocaicum]
ATGGGATTTCTGGACAAGGTGAAGGACCTGGCGGCGCAGAACGCCGACAAGGTCGAAGCCGCTATCGAGAAGGTCGGCGA
CATCGTCGACGAGAAGACCGAAGGCAAGTTCAAGGGCGCGGTCGACAGCGCCCAGGAGGCGGCGAAGAAGGCTGTGGCCG
GCGACCAGTCTGCTGAGGCTCCCGCCGCGCCGCCGGCCGAGGGGACGCAAGAACAGCAGTAG

Structures

Toxin

• AlphaFold DB: A0A331XLA5

Antitoxin

• AlphaFold DB: A0A0H3GXD8