Detailed information of TA system TA179337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 123897..125485
• Replicon: chromosome
• Accession: NZ_CP063906
• Organism: Klebsiella pneumoniae strain BM327-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486JB51
• Locus tag: ISA83_RS00675
• Protein ID: WP_023316847.1
• Coordinates: 124163..125485 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: ISA83_RS00670
• Protein ID: WP_002904790.1
• Coordinates: 123897..124163 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA83_RS00645	119048..119971	+	924	WP_023297602.1	LysR family hpxDE operon transcriptional regulator HpxR	-
ISA83_RS00650	119952..121106	-	1155	WP_008804924.1	FAD-dependent urate hydroxylase HpxO	-
ISA83_RS00655	121452..122831	+	1380	WP_032412205.1	purine permease	-
ISA83_RS00660	122809..123309	+	501	WP_032412207.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
ISA83_RS00665	123306..123632	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
ISA83_RS00670	123897..124163	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
ISA83_RS00675	124163..125485	+	1323	WP_023316847.1	type II toxin-antitoxin system HipA family toxin	Toxin
ISA83_RS00680	125502..126794	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
ISA83_RS00685	126936..127940	-	1005	WP_032412210.1	type 1 fimbrial protein	-
ISA83_RS00690	127928..130429	-	2502	WP_032412215.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T179337 WP_023316847.1 NZ_CP063906:124163-125485 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T179337 NZ_CP084704:2616062-2616244 [Desulfurispirillum indicum]
ATGAATAGTAGGCAACTGATCAAACAACTGGAAGAGGATGATTGGTTTTTGGCAAGAGTCAAAGGCTCGCATCATCAATT
CAAACATCAAACCAAGCCAGGATTAGTGACAGTTAAGCACCCTGACAGTGATATTCCCGCCGGTACACTGAATAACATTC
GCAAGCAGGCGGGTTGGAAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT179337 WP_002904790.1 NZ_CP063906:123897-124163 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT179337 NZ_CP084704:2616254-2616646 [Desulfurispirillum indicum]
ATGCGTTTTCCCGTAGTGTTGCATACTGATGATGGAGTGCGCTTCGGTGTGACGGTGCCTGATTTGCCAGGTTGTTATTC
CGCTGGCGATACCTTTGATGCTGCATTGGATTCTGTACTGGAAGCTATCGACCTTCATTTAGAAGGATTGACCGAGGATG
GTGCAGATATTCCCATTCCTCGCCCGATTGCTGAACATCGCACGAATCATGATTTCGCGGATGGGGTATGGGCGGCAGTC
GATGTCGATATATCCCGATTCGAGGGACGCTCCGAGAAAATAAACATCACCTTACCTCGGCGCTTATTGGCGAAGATCGA
TAGCTACGCCAACGCCCATGGTAAATCACGTTCCGGTTTTCTCGCTGAGGCGGCGCGGGCAGCAATGCGCTAA

Structures

Toxin

• AlphaFold DB: A0A486JB51

Antitoxin

• AlphaFold DB: A0A0H3GXD8