Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4853770..4854427 Replicon chromosome
Accession NZ_CP063904
Organism Klebsiella pneumoniae strain BM334-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA84_RS23610 Protein ID WP_002916310.1
Coordinates 4854017..4854427 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA84_RS23605 Protein ID WP_002916312.1
Coordinates 4853770..4854036 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA84_RS23580 4848927..4850360 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
ISA84_RS23585 4850479..4851207 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISA84_RS23590 4851256..4851567 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISA84_RS23595 4851731..4852390 + 660 WP_002916317.1 hemolysin III family protein -
ISA84_RS23600 4852541..4853524 - 984 WP_022615657.1 tRNA-modifying protein YgfZ -
ISA84_RS23605 4853770..4854036 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA84_RS23610 4854017..4854427 + 411 WP_002916310.1 protein YgfX Toxin
ISA84_RS23615 4854434..4854955 - 522 WP_002916308.1 flavodoxin FldB -
ISA84_RS23620 4855056..4855952 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA84_RS23625 4855975..4856688 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA84_RS23630 4856694..4858427 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179334 WP_002916310.1 NZ_CP063904:4854017-4854427 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179334 NZ_CP084704:905406-906332 [Desulfurispirillum indicum]
ATGAGCCAGGATAAAAAGGGGAACATTGCGCATTCAATTTCTCAGCGGCTACTGAACCGTGCCAAAGCAAACAAAGAGGA
TTTTAATTTTCTGCTTTCGCGTTACGGGATGGAGCGTTTCCTTTATCGGATCAGCATTTCTCCACATGCTGACCGGTTGA
TCTTAAAGGGAGCCAGCCTGTTTCTGGTTTGGGCAGGGCAGAATCATCGTGTCTCCCGGGATGTGGATTTTCTCGGGTTT
GGCAATCCGGATGCGGATCAGCTCGCAGAGATATTTCTAGATGTCTGCTGTATTGAGTCTCCGGATGATGGCATGATTTA
TCTCTGTGACTCGCTGAAGACTGAGGCGATCTGTGAAGGTCAGGAGTATGATGGGGTGCGGATCACTTTAGTTGGTCTGC
TTGATCGGGCCCGCATTCCTCTTCAGTTTGATATTGGATTTGGTGATATTGTAACGCCTGCGCCTGAAAACGTCGAGTAT
CCGGTACTTCTTGATTATCCTCCACCGCTCCTGAGAGCGTATCCACGCTATACACTTGTGGCTGAAAAGACGGAGGCAAT
GGTCAGACTTGGTTTGGCAAACAGTCGTCTGAAAGATTTTTATGATATCTGGCTTGTTTCCAGGCTCTTCTCGTTTGAAG
GAAGTATTTTGCAGAAGGCTTTGCAAAACACCTTTGAGCGGCGACGCACGGCGCTGCCAGAATCAATACCTTTTGCATTC
ACACCAGCTTTTTATGACGACGCCCAAAAGAGAATTCAGTGGACAGCTTTCGTGAAAAAATCGAAGCCCAGCATTCCGAT
TTACGATTTGACTACGATTATCACGGATATATCTGATTTTCTCGTACCAGTTGTAAAAGGCCTGCTGTTAAATGATCCCT
TTGAATGTACGTGGTTGCCTGACCATGGGTGGAGTGGTGAGTCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179334 WP_002916312.1 NZ_CP063904:4853770-4854036 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179334 NZ_CP084704:904813-905409 [Desulfurispirillum indicum]
ATGAGCAGACGGCATCAGATACTGGAACTTGTCAGCAAAAAAGGAATTATCAGGGCTGAAGATGTTGAGGCTATGGGTAT
TTCCCGGAATTACCTGTTCTGGATGCACCGGGAGGGGTATCTGGAGAGGATTGCTGTAGGGGTCTATGCCTTGCCTGATG
CTCCCGTTTCTGAAGGCTCAACTTTGGCTGAAGTTGCAACAAGGATGCCTCGCGCTGTTGTCTGCCTTGTTTCCGCACTC
AATTTTCATGGGATTACCTCCCAGCTTTCCCCTGAGATATGGTTGACGATTCCCCGTGGGTCGTGGAAACCGGATATGCA
ATATCCACCTCTTAACCTGACGTATGTTTCGGAGCCTGCCTATTCATTCGGCATTCAGGAACATGTCGTCAATGGCGTGC
TGGTAAAGGTCTACAGCCCAGCAAAAACGGTGGCGGATTGCTTTAAATTCCGCAGCAAAGTGGGTCTTGATATTGCCATA
GAGGGGCTTCGAGAAGCCTGGCGATCACGCAAAGTCACGATGGATGAGCTAATGGAGGCCGCTGAGGTTAACAGGGTATC
AAAAGTTATGCGTCCATACCTGGAGGCCGTTGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References