Detailed information of TA system TA179331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3657721..3659402
• Replicon: chromosome
• Accession: NZ_CP063904
• Organism: Klebsiella pneumoniae strain BM334-2

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: ISA84_RS17840
• Protein ID: WP_002885155.1
• Coordinates: 3657721..3658638 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A2L1C4M5
• Locus tag: ISA84_RS17845
• Protein ID: WP_004192584.1
• Coordinates: 3658644..3659402 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA84_RS17820	3653027..3654547	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
ISA84_RS17825	3654544..3655542	+	999	WP_004146665.1	ribose ABC transporter permease	-
ISA84_RS17830	3655573..3656514	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
ISA84_RS17835	3656589..3657596	+	1008	WP_004210019.1	carbohydrate kinase family protein	-
ISA84_RS17840	3657721..3658638	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ISA84_RS17845	3658644..3659402	-	759	WP_004192584.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ISA84_RS17850	3659488..3660216	-	729	WP_004210017.1	response regulator transcription factor	-
ISA84_RS17855	3660489..3662636	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
ISA84_RS17860	3662866..3663552	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T179331 WP_002885155.1 NZ_CP063904:c3658638-3657721 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T179331 NZ_CP084699:688503-688778 [Rhizobium ruizarguesonis]
ATGGGGATCAAGTGGACGAGCAAAGCGGCCTCGGACGTCGCCCGCTTGTACGACTTTCTCACTCCGGTCGACAGGCAAGC
GGCGGTCCGAACAGTGCGGGCACTGACGGCAGCGCCTGCACGGCTGCTTGAGCAGCCGCGCCTCGGCGAGCGGCTCGAGG
AGTTCGATCCTCGAGAGGTCCGCCGTATTCTCGTCGGTCGTTGCGAGCTGCGCTATGAAATCCAGCAGTCGATGATCTAT
GTATTGCGCCTTTGGCATACGCGTGAGGACAGGTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28582.94 Da
• Isoelectric Point: 10.0870

>AT179331 WP_004192584.1 NZ_CP063904:c3659402-3658644 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT179331 NZ_CP084699:688243-688503 [Rhizobium ruizarguesonis]
ATGGAGACCAAGGTTCTGACTGCTCATGTTCCGCTGCCGCTTGCGCAAAAGGTTGATCAACTCGCGTCGCGGCTCGAACG
CTCGCGTGGTTGGATCGTCAAGCAGGCTCTCACGGCATGGATCGACCAGGAGGAGGAGCGCCGGCGTTTGACGCTCGAGG
CGTTGGCCGACGTCGATGACGGTAACCTTGTCGAGCACCAGTCTGTTCAAGCCTGGGCCGATAGTCTTGATAGCGACGAG
CCGATTTCTTTGCCTCGGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A2L1C4M5