Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3499955..3500471 Replicon chromosome
Accession NZ_CP063904
Organism Klebsiella pneumoniae strain BM334-2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag ISA84_RS17045 Protein ID WP_004178374.1
Coordinates 3499955..3500239 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ISA84_RS17050 Protein ID WP_002886901.1
Coordinates 3500229..3500471 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA84_RS17020 3495438..3495746 - 309 WP_004210629.1 PTS sugar transporter subunit IIB -
ISA84_RS17025 3495831..3496004 + 174 WP_004210630.1 hypothetical protein -
ISA84_RS17030 3496007..3496750 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ISA84_RS17035 3497107..3499245 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
ISA84_RS17040 3499487..3499951 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISA84_RS17045 3499955..3500239 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA84_RS17050 3500229..3500471 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISA84_RS17055 3500549..3502459 - 1911 WP_004152270.1 BglG family transcription antiterminator -
ISA84_RS17060 3502482..3503636 - 1155 WP_004210635.1 lactonase family protein -
ISA84_RS17065 3503703..3504443 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T179330 WP_004178374.1 NZ_CP063904:c3500239-3499955 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T179330 NZ_CP084699:273240-273665 [Rhizobium ruizarguesonis]
ATGATCCTGATCGATACCAACGTCATCTCGGAGCCATGGAAACCCACACCCGATAATCAGGTGCTGGCGTGGATCGATGT
CCAAGCAGTGGAAACGCTGTTCGTTTCAGCGATTACAGTGGCTGAGTTACGGTTCGGCATTGCCGCGATGCCTAGCGGAA
GGCGAAAGACCGTCCTCGACGATCGACTAGAACAGGAAGTTCTGCCTCTATTTTCAGGACGCGTTCTATCCTTCGACATG
GCTGCATCACAGAGCTATTCGGAATTAATGGCGCGAGCACGCGCAGCAGGTCGGGCAATCGGTAAAGCAGATGCCTATAT
TGCCGCAACTGCCGCGGCGAACGGATTTATTGTCGCTACCCGCGACTCTAGTCCCTTCGAAGCCGCAGGGCTTAAGGTTA
TCAACCCTTGGTACGCACCAACGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179330 WP_002886901.1 NZ_CP063904:c3500471-3500229 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179330 NZ_CP084699:272989-273243 [Rhizobium ruizarguesonis]
ATGGCAGCAGTTACAATACGCAATTTGTCTGACGAGACACATCGTGCTTTGAGAGTGAGGGCAGCTCATCACGGCCGCAG
TACCGAAGCAGAAATCCGTGACATCCTAGAAACAGCGGTACGGCCAGCTGAACGCGTGATGTTGGGCTCGTTGCTAGCAT
CAATCGGACGCGAGGCAGGGCTTTCGAACGACGACGTGGATAATCTGCAGCTCGTCCGAGACAAAACGCCTGCGGAACCT
ATGAGTTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References