179327

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2776332..2776951 Replicon chromosome
Accession NZ_CP063904
Organism Klebsiella pneumoniae strain BM334-2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISA84_RS13630 Protein ID WP_002892050.1
Coordinates 2776733..2776951 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISA84_RS13625 Protein ID WP_002892066.1
Coordinates 2776332..2776706 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA84_RS13615 2771484..2772677 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ISA84_RS13620 2772700..2775846 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
ISA84_RS13625 2776332..2776706 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISA84_RS13630 2776733..2776951 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISA84_RS13635 2777110..2777676 + 567 WP_002892030.1 maltose O-acetyltransferase -
ISA84_RS13640 2777648..2777788 - 141 WP_004147370.1 hypothetical protein -
ISA84_RS13645 2777809..2778279 + 471 WP_002892026.1 YlaC family protein -
ISA84_RS13650 2778254..2779705 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
ISA84_RS13655 2779806..2780504 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
ISA84_RS13660 2780501..2780641 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISA84_RS13665 2780641..2780904 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179327 WP_002892050.1 NZ_CP063904:2776733-2776951 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179327 NZ_CP084696:745470-745697 [Rhizobium ruizarguesonis]
ATGAAAAAGATCGCCTACAGCAAGGCTGCCGCGAAGGCACTTCGCAAGATGCAGCCGAAGCGCGCCGCGGCGATCGTCGC
CAACGGCGAGATGGTCGATCTCAAGAAGCTGCAAGACAGCGAATTTTTTCGAATTCGTGTCGGGCAGGACCGCGTCATCA
TCGACGATCAGACCATGCAGGTCCTCGTCATCAAGGCCGGCCCACACGGCGACATCTATAACGAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179327 WP_002892066.1 NZ_CP063904:2776332-2776706 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179327 NZ_CP084696:745707-746054 [Rhizobium ruizarguesonis]
ATGGGTGAAATCCAGAAACTGACTATCGACGGCAAGGGGTACGTACTGCTTTCCGAAGACGACTATCAGGACCTTGTCGA
CGTCAGCGACGCGCGTGCCGCAAAGGCGCGTATCGACGCTGGTGAAGAGACCTGGCCTGAAGACGTCGTCAAGGCGCTGA
TCGCCGGCGAAGATCCTGTCCGGGTGTTCCGTAAGCATCGCGGCATGAGTATCAAGGAACTGGCTGAAAAGTCCGGGCTC
TCCCAGCCCTATCTTTCCGAAATCGAGACCGGAAAGAAGGAGGGCTCCCTGGACGCACTCAGGTCGATCGCCAGCGCGCT
GGACGTCGACCTTGACGATGTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References