Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3612036..3612693 Replicon chromosome
Accession NZ_CP063902
Organism Klebsiella quasipneumoniae strain BS419-3

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag ISA85_RS17495 Protein ID WP_004205323.1
Coordinates 3612283..3612693 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA85_RS17490 Protein ID WP_002916312.1
Coordinates 3612036..3612302 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA85_RS17465 3607245..3608678 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
ISA85_RS17470 3608797..3609525 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
ISA85_RS17475 3609575..3609886 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
ISA85_RS17480 3610049..3610708 + 660 WP_004205319.1 hemolysin III family protein -
ISA85_RS17485 3610807..3611790 - 984 WP_122542307.1 tRNA-modifying protein YgfZ -
ISA85_RS17490 3612036..3612302 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA85_RS17495 3612283..3612693 + 411 WP_004205323.1 protein YgfX Toxin
ISA85_RS17500 3612700..3613221 - 522 WP_004205324.1 flavodoxin FldB -
ISA85_RS17505 3613322..3614218 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA85_RS17510 3614241..3614954 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA85_RS17515 3614960..3616693 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T179307 WP_004205323.1 NZ_CP063902:3612283-3612693 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179307 NZ_CP084683:c1390638-1390342 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179307 WP_002916312.1 NZ_CP063902:3612036-3612302 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179307 NZ_CP084683:c1390340-1389945 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References