Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2251606..2252119 Replicon chromosome
Accession NZ_CP063902
Organism Klebsiella quasipneumoniae strain BS419-3

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag ISA85_RS10860 Protein ID WP_017900571.1
Coordinates 2251606..2251887 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ISA85_RS10865 Protein ID WP_048322784.1
Coordinates 2251877..2252119 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA85_RS10850 2248617..2250755 + 2139 WP_080838453.1 anaerobic ribonucleoside-triphosphate reductase -
ISA85_RS10855 2251138..2251602 + 465 WP_023319597.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISA85_RS10860 2251606..2251887 - 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA85_RS10865 2251877..2252119 - 243 WP_048322784.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISA85_RS10870 2252197..2254107 - 1911 WP_004206509.1 BglG family transcription antiterminator -
ISA85_RS10875 2254130..2255284 - 1155 WP_065697356.1 lactonase family protein -
ISA85_RS10880 2255447..2256187 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T179306 WP_017900571.1 NZ_CP063902:c2251887-2251606 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

>T179306 NZ_CP084683:870446-870549 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9117.61 Da        Isoelectric Point: 5.1486

>AT179306 WP_048322784.1 NZ_CP063902:c2252119-2251877 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPEVKVSLDDL

Download         Length: 243 bp

>AT179306 NZ_CP084683:c870587-870316 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure

References