Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 156873..157624 Replicon plasmid pBS324-2
Accession NZ_CP063901
Organism Klebsiella quasipneumoniae strain BS324-2

Toxin (Protein)


Gene name ataT Uniprot ID A0A486R6L7
Locus tag ISA86_RS25590 Protein ID WP_041165502.1
Coordinates 157142..157624 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6S4YWG5
Locus tag ISA86_RS25585 Protein ID WP_012540170.1
Coordinates 156873..157151 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA86_RS25570 152513..153397 - 885 WP_004186900.1 hypothetical protein -
ISA86_RS25575 154642..155100 + 459 WP_014386535.1 hypothetical protein -
ISA86_RS25580 156029..156565 - 537 WP_064190144.1 hypothetical protein -
ISA86_RS25585 156873..157151 + 279 WP_012540170.1 DUF1778 domain-containing protein Antitoxin
ISA86_RS25590 157142..157624 + 483 WP_041165502.1 GNAT family N-acetyltransferase Toxin
ISA86_RS25595 157662..158066 + 405 WP_048293664.1 DUF2251 domain-containing protein -
ISA86_RS25600 158386..159219 + 834 WP_012540133.1 GIY-YIG nuclease family protein -
ISA86_RS25605 159283..159480 + 198 WP_077264171.1 bacteriocin immunity protein -
ISA86_RS25610 159575..159811 - 237 WP_012540047.1 hypothetical protein -
ISA86_RS25615 160856..161584 + 729 WP_012540055.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..176438 176438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17697.61 Da        Isoelectric Point: 9.4948

>T179303 WP_041165502.1 NZ_CP063901:157142-157624 [Klebsiella quasipneumoniae]
MGMRPPEPLTPEHNIADFCCQDQVLSEWLKKKALKNHSTGLSRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTQHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

>T179303 NZ_CP084664:c4326098-4325787 [Hafnia paralvei]
ATGGAAAAGCGAACACCGCATTGCCGATTAGAAAAGATACGGAGTCTGATAGGAAAGGGGTTGATTAGAGCAACTAAATC
AGCACATCGAAATGCCGAGTTGATCAATTTCAGCCTTGCGGATATGTATCGTGTTGTCAGTGAACTTTCCCCACACGATT
TTTATAAAAGTATGACCGCTTATGATGATCATCGAATTTGGCAAGATGTTTATTATTGCCATCTGGACACCATCTCTCTT
TATCTAAAATTGACGGTAATTGATGATGTTTTAATCGTATCCTTTAAGGAGTTAGATCATGCAGTGTCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10749.33 Da        Isoelectric Point: 4.6722

>AT179303 WP_012540170.1 NZ_CP063901:156873-157151 [Klebsiella quasipneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDKQFNAFVEELDAPMTPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT179303 NZ_CP084664:c4325800-4325402 [Hafnia paralvei]
ATGCAGTGTCCTGAATGTGGTTCTAAAAACACGGTTAAGGAATATCGTGATATCCCTTTTACCTATAAAGGCCAGTCTAC
GGTAGTAAAAGCTGTCGGAGCTGACTGGTGTTTGAACTGTGGCGAAGGGGTTATTTTCAAAGAAGAATCTCTACGTATTG
ATGGCATTCTGAGCGAGTTTAACAAACAGGTAAATGCCTCTATCATTGAACCTGAGTTCGTTATCGCGATGCGAAAAAAG
CTTAATCTGTCTCAAAGTGAGGCCGGTGAGATCTTTGGCGGTGGGGTCAACGCCTTCTCACGCTATGAGACAGGCAAGGC
TCTTCCCCATGTTTCCACCATCAAACTGTTAAAGCTGTTAGATAAACATCCCGAACTGCTCGCTGAAATCCGCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486R6L7

Antitoxin

Source ID Structure
AlphaFold DB A0A6S4YWG5

References