Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4366670..4367289 Replicon chromosome
Accession NZ_CP063900
Organism Klebsiella quasipneumoniae strain BS324-2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISA86_RS21195 Protein ID WP_002892050.1
Coordinates 4366670..4366888 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISA86_RS21200 Protein ID WP_002892066.1
Coordinates 4366915..4367289 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA86_RS21160 4362713..4362976 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
ISA86_RS21165 4362976..4363116 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISA86_RS21170 4363113..4363811 - 699 WP_004204753.1 GNAT family N-acetyltransferase -
ISA86_RS21175 4363912..4365369 + 1458 WP_049117056.1 PLP-dependent aminotransferase family protein -
ISA86_RS21180 4365338..4365808 - 471 WP_004204751.1 YlaC family protein -
ISA86_RS21185 4365851..4365973 + 123 WP_032426076.1 hypothetical protein -
ISA86_RS21190 4365945..4366511 - 567 WP_004204750.1 maltose O-acetyltransferase -
ISA86_RS21195 4366670..4366888 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISA86_RS21200 4366915..4367289 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISA86_RS21205 4367774..4370920 - 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
ISA86_RS21210 4370943..4372136 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179299 WP_002892050.1 NZ_CP063900:c4366888-4366670 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179299 NZ_CP084664:2064274-2064798 [Hafnia paralvei]
ATGCCAGATCTCGCTATTGAGATTTTTTCGAACGACATCGAATATGATTTTGCTCATTTCGACTGTGGTGAAGAATCTCT
CAATATATTCCTCACCAATCATCTTGCCCGCCAGCACAACGCTCGAATCTTACGGGGTTATTTGCTGGTCACCAAAGAGC
CAAAACCTAAAGTCGTAGGATATTACACGTTATCTGGCAGTTGCTTCGAGAAAGAAACGCTTCCTTCAAACACACAGAAA
CGGAAAGTACCTTACGCTAATGTGCCCAGCGTCACCTTGGGGCGACTGGCTATCCAAAAAGAGTTGCAGGGACAAGACTG
GGGAACAACGCTGGTAACTCATGCTATGAAAGTCATCTATCACGCGTCACTGGCGGTCGGCATCCATGGTATGTTTGTTG
ATGCCCTTAACGAAAAAGCCAAGCGGTTCTATCTTCAACTTGGTTTTATTGCGCTTACAGGCAATAACGCAAACTCGTTG
TTCTACCCAACAAAATCCATCGAAAAGCTGTTTGAAGACGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179299 WP_002892066.1 NZ_CP063900:c4367289-4366915 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179299 NZ_CP084664:2064001-2064270 [Hafnia paralvei]
ATGTCCGCCCTAAAAAAACAACGTATCGATCTCAGACTCACCGATGATGACAAAAGCAAGATCGAAGAAGCGGCCGCAAT
GACCAACCAAACTATCACCCAGTTTATGGTTGCTAGCGCCGCTGAACGCGCAGAGGAAGTCATTGAGCAGCATCGTCGTC
TCGTTCTCAACGATGAGTCGTGGAATTTGGTGATGGACGCTATCAGCAATCCGCCAGCCCCGAACAGTCGGCTGAAACGA
GCAGCGAAACGTCTAGCAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References