Detailed information of TA system TA179297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2793234..2793820
• Replicon: chromosome
• Accession: NZ_CP063900
• Organism: Klebsiella quasipneumoniae strain BS324-2

Toxin (Protein)

• Gene name: doc
• Uniprot ID: W8VD46
• Locus tag: ISA86_RS13850
• Protein ID: WP_002920800.1
• Coordinates: 2793234..2793602 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: ISA86_RS13855
• Protein ID: WP_040221757.1
• Coordinates: 2793599..2793820 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA86_RS13830	2788661..2789731	-	1071	WP_004150074.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
ISA86_RS13835	2789733..2790578	-	846	WP_004202115.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
ISA86_RS13840	2790575..2791462	-	888	WP_002920792.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
ISA86_RS13845	2791569..2792885	-	1317	WP_004174008.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
ISA86_RS13850	2793234..2793602	-	369	WP_002920800.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
ISA86_RS13855	2793599..2793820	-	222	WP_040221757.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ISA86_RS13860	2793984..2794697	-	714	WP_004145133.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
ISA86_RS13865	2794699..2795466	-	768	WP_002920803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
ISA86_RS13870	2795463..2796740	-	1278	WP_004202111.1	branched chain amino acid ABC transporter permease LivM	-
ISA86_RS13875	2796737..2797663	-	927	WP_002920807.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2787924..2796740	8816

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (13-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-51)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13552.92 Da
• Isoelectric Point: 8.6410

>T179297 WP_002920800.1 NZ_CP063900:c2793602-2793234 [Klebsiella quasipneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Nucleotide

• Length: 369 bp

>T179297 NZ_CP084664:419097-419510 [Hafnia paralvei]
GTGGACCAATGGCGTTGTGATGTGCGGGTGTCATGGCGTACACAACTATTACTGTTGGTGACGCATGGCACTCTGGTTTT
ATTGATTTTGTTAGCTCCTTGGCCGGAAAACTACAGTATTTATTGGCTCATTTTGCTGACATTAGTGGTGTTTGAAAGTA
TTCGCAGCCAGAAGCAGATTGCTAAGGTTCAGGGAGAGTTGAATTTTCTGGCGGAAAATCGCATTAGTTGGCAGCACCAA
GAATGGGAGCTATGTAAGACGCCGTGGATCAGTGATTTTGGCGCTTTGCTACCGTTGAAGAGTTTGAAGGATCAGGATAA
AAGAAAGCGTTTGTGGATTGCAGCAGATAGCCTGACGCCAGAAGCGTGGTCTCATTTGCGACGCAGTTTAATGCAGATGC
GTCATGATGCTTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8133.12 Da
• Isoelectric Point: 4.7769

>AT179297 WP_040221757.1 NZ_CP063900:c2793820-2793599 [Klebsiella quasipneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARIDDEFAAIMAVHGDEIRELADK

Nucleotide

• Length: 222 bp

>AT179297 NZ_CP084664:418850-419116 [Hafnia paralvei]
ATGGATATAGAAAATAAATCACGAATTCATTGGGCGTGTCGCCGTGGGATGCGTGAACTGGATATCTCTATTATGCCGTT
TTTCGAACATGAGTATGATTCACTGAGTGACACAGACAAGCAGACATTTGTACGCTTACTTGAGTGCGACGATCCCGATC
TTTTTAATTGGCTAATGAATCACGGCTCACCAAAAGATCCTGAATTGGCGCATATGGTTAAACTCATTCAAACGCGAAAC
AAAGACCGTGGACCAATGGCGTTGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GUD1