Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2340965..2341622 Replicon chromosome
Accession NZ_CP063900
Organism Klebsiella quasipneumoniae strain BS324-2

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag ISA86_RS11515 Protein ID WP_004205323.1
Coordinates 2340965..2341375 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA86_RS11520 Protein ID WP_002916312.1
Coordinates 2341356..2341622 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA86_RS11495 2336965..2338698 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
ISA86_RS11500 2338704..2339417 - 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA86_RS11505 2339440..2340336 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA86_RS11510 2340437..2340958 + 522 WP_109938288.1 flavodoxin FldB -
ISA86_RS11515 2340965..2341375 - 411 WP_004205323.1 protein YgfX Toxin
ISA86_RS11520 2341356..2341622 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA86_RS11525 2341868..2342851 + 984 WP_017899798.1 tRNA-modifying protein YgfZ -
ISA86_RS11530 2342950..2343609 - 660 WP_004205319.1 hemolysin III family protein -
ISA86_RS11535 2343772..2344083 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISA86_RS11540 2344134..2344862 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
ISA86_RS11545 2344981..2346414 + 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T179296 WP_004205323.1 NZ_CP063900:c2341375-2340965 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179296 NZ_CP084656:4014933-4015211 [Pectobacterium versatile]
ATGAAAAAGCAAAGGGAGATTGCATATTCTGGTCAATTCCAACGTGATGTGAAAAAAGCTCAACGGCGACATAAAAACAT
GAACAAGCTTAAAACGCTTATGCAGCTTTTGCTTGAAGACAAACGACCGTTGCCACAGGAATATCAGGATCACCCCCTCC
AGGGAAACTATAAGGGCTACAGAGATGCGCATATCGAGCCGGATTGGCTTCTTATTTACAAGCTGACCGATGACGTTTTG
CGTTTTGAACGTACAGGGACGCACGCTGACCTTTTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179296 WP_002916312.1 NZ_CP063900:c2341622-2341356 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179296 NZ_CP084656:4014669-4014929 [Pectobacterium versatile]
ATGGCAGCGAATGCATTTGTACGTGCCCGTATTGATGAGAATCTTAAAAATGAAGCAGCGGAAGTGTTGGCTAGCATGGG
GTTGACGGTATCGGATCTGGTGCGCATAACGTTAACGAAAGTGGCTAAAGAAAAAGCGCTTCCATTTGATATGCATGTCC
CTAATAAGCTTACCGCACAAACGATGGCTGACAGCGAGAAAGGGGTTGATGTCCATACAGCAAAAGACGCCGCCGATCTG
TTTGATAAATTAGGGATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References