Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4957052..4957709 Replicon chromosome
Accession NZ_CP063898
Organism Klebsiella variicola strain BS326-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISA87_RS23760 Protein ID WP_002916310.1
Coordinates 4957052..4957462 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA87_RS23765 Protein ID WP_002916312.1
Coordinates 4957443..4957709 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA87_RS23740 4953052..4954785 - 1734 WP_117115731.1 single-stranded-DNA-specific exonuclease RecJ -
ISA87_RS23745 4954791..4955504 - 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA87_RS23750 4955527..4956423 - 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
ISA87_RS23755 4956524..4957045 + 522 WP_008806427.1 flavodoxin FldB -
ISA87_RS23760 4957052..4957462 - 411 WP_002916310.1 protein YgfX Toxin
ISA87_RS23765 4957443..4957709 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA87_RS23770 4957955..4958938 + 984 WP_012967246.1 tRNA-modifying protein YgfZ -
ISA87_RS23775 4958985..4959323 - 339 WP_155870248.1 hypothetical protein -
ISA87_RS23780 4959354..4960013 - 660 WP_008806429.1 hemolysin III family protein -
ISA87_RS23785 4960177..4960488 - 312 WP_117115733.1 N(4)-acetylcytidine aminohydrolase -
ISA87_RS23790 4960539..4961267 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179281 WP_002916310.1 NZ_CP063898:c4957462-4957052 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179281 NZ_CP084656:c2616478-2616299 [Pectobacterium versatile]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCTAGCAAACCGGGGTTAGTCACCATCCCCCACCCTAAGAAAGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179281 WP_002916312.1 NZ_CP063898:c4957709-4957443 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179281 NZ_CP084656:c2616271-2615861 [Pectobacterium versatile]
ATGTTTTATCCGATTGCAATTGAAGCAGGCGACGATACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTTATCGAGA
TGGGTCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTGGCAAAAAACGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATCGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAACGTTACACTGCCTAAGTCGCTGATTGACCGCAT
TGATCGTTGCGTGGCAAGTAATCCTGAATTTAAAAGCCGCTCAGGGTTTCTCGCGCAGGCAGCATTAGAGCGAATCTCGT
CTTCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References