Detailed information of TA system TA179268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 679869..681550
• Replicon: chromosome
• Accession: NZ_CP063898
• Organism: Klebsiella variicola strain BS326-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: ISA87_RS03120
• Protein ID: WP_088717438.1
• Coordinates: 680633..681550 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ISA87_RS03115
• Protein ID: WP_039102729.1
• Coordinates: 679869..680627 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA87_RS03100	675684..676370	-	687	WP_016160120.1	sel1 repeat family protein	-
ISA87_RS03105	676636..678783	-	2148	WP_117115692.1	formate dehydrogenase subunit alpha	-
ISA87_RS03110	679056..679784	+	729	WP_008807258.1	response regulator transcription factor	-
ISA87_RS03115	679869..680627	+	759	WP_039102729.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ISA87_RS03120	680633..681550	+	918	WP_088717438.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ISA87_RS03125	681675..682682	-	1008	WP_022065799.1	carbohydrate kinase family protein	-
ISA87_RS03130	682757..683698	-	942	WP_008807254.1	ABC transporter substrate-binding protein	-
ISA87_RS03135	683729..684727	-	999	WP_023296904.1	ribose ABC transporter permease	-
ISA87_RS03140	684724..686244	-	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34761.16 Da
• Isoelectric Point: 5.4707

>T179268 WP_088717438.1 NZ_CP063898:680633-681550 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLVPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T179268 NZ_CP084655:2054803-2055078 [Pectobacterium brasiliense]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTAAGCCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAATATTGAGTCACTTGTTACTGCGTTAGGTGGTGAAATTAAGGAAGGTAGCGGATCGCGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCACTGGTTAGCCTG
CGTGAATGGCTAGAAAGTATAGGAGTAAAACCATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28642.97 Da
• Isoelectric Point: 10.1988

>AT179268 WP_039102729.1 NZ_CP063898:679869-680627 [Klebsiella variicola]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT179268 NZ_CP084655:2055075-2055437 [Pectobacterium brasiliense]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCGGCCATTATCAGTTACGTACCGGAAATTGG
TATGTTTCGCGGTAAATTTATTGGTTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGACTGACCACTGCGGCCGCTGAACGTCAAATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACTTGAAACAGGCTTAA