Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5045637..5047225 Replicon chromosome
Accession NZ_CP063896
Organism Klebsiella quasipneumoniae strain BS419-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag ISA88_RS24485 Protein ID WP_043519554.1
Coordinates 5045637..5046959 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag ISA88_RS24490 Protein ID WP_004205921.1
Coordinates 5046959..5047225 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA88_RS24450 5040719..5040937 + 219 WP_002904808.1 ParD-like family protein -
ISA88_RS24455 5040918..5041700 + 783 WP_049003659.1 type I methionyl aminopeptidase -
ISA88_RS24460 5041969..5043084 + 1116 WP_004205914.1 serine hydrolase -
ISA88_RS24465 5043071..5043415 + 345 WP_004205915.1 hypothetical protein -
ISA88_RS24470 5043444..5043977 + 534 WP_004205916.1 hypothetical protein -
ISA88_RS24475 5043980..5044186 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
ISA88_RS24480 5044328..5045620 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
ISA88_RS24485 5045637..5046959 - 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
ISA88_RS24490 5046959..5047225 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ISA88_RS24495 5047508..5047834 - 327 WP_064794852.1 hydroxyisourate hydrolase -
ISA88_RS24500 5047831..5048331 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ISA88_RS24505 5048309..5049688 - 1380 WP_017900377.1 purine permease -
ISA88_RS24510 5050034..5051188 + 1155 WP_053810396.1 FAD-dependent urate hydroxylase HpxO -
ISA88_RS24515 5051169..5052092 - 924 WP_053810397.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T179265 WP_043519554.1 NZ_CP063896:c5046959-5045637 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

>T179265 NZ_CP084655:1760195-1760482 [Pectobacterium brasiliense]
ATGAGTTATAGCGTTAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACTATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCGGCAAAGTTACGGGGGACGAAGGACTGCTACAAAATAA
AGCTCCGAGCGTCAGGCTTTCGTTTGATTTATGAGGTTATTGACGACGTATTGATTATCGCCGTAGTGGCGGTAGGCAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGTGAGTGAGCGAATGAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT179265 WP_004205921.1 NZ_CP063896:c5047225-5046959 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT179265 NZ_CP084655:1759947-1760198 [Pectobacterium brasiliense]
ATGCCGAATATTATATTGAGTGATACCAGTGCTAGCGTCAGTGAACTGAAAAAGAACCCGATGGCGACGGTCAATGCTGG
CGATGGTCTACCTGTCGCTATTTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGGTTAAGCTAATCGGTGAACGTAAAAACCAGCCGCTGGTTGACGTGGATTTGGAT
AGTTTTCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References