Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3224053..3224710 Replicon chromosome
Accession NZ_CP063896
Organism Klebsiella quasipneumoniae strain BS419-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag ISA88_RS15610 Protein ID WP_004205323.1
Coordinates 3224300..3224710 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISA88_RS15605 Protein ID WP_002916312.1
Coordinates 3224053..3224319 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA88_RS15580 3219262..3220695 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
ISA88_RS15585 3220814..3221542 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
ISA88_RS15590 3221592..3221903 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
ISA88_RS15595 3222066..3222725 + 660 WP_004205319.1 hemolysin III family protein -
ISA88_RS15600 3222824..3223807 - 984 WP_122542307.1 tRNA-modifying protein YgfZ -
ISA88_RS15605 3224053..3224319 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISA88_RS15610 3224300..3224710 + 411 WP_004205323.1 protein YgfX Toxin
ISA88_RS15615 3224717..3225238 - 522 WP_004205324.1 flavodoxin FldB -
ISA88_RS15620 3225339..3226235 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISA88_RS15625 3226258..3226971 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISA88_RS15630 3226977..3228710 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T179256 WP_004205323.1 NZ_CP063896:3224300-3224710 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179256 NZ_CP084654:4926062-4926349 [Pectobacterium versatile]
ATGAGTTATCGCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGCTCAAACTCGATAAAGCTATCCAACAACAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTGCGGCAAAGTTACGGGGAATGAAGGATTGCTACAAAATAA
AGCTCCGAGCATCAGGCTTTCGTTTGGTTTATGAGGTTATTGACGACGTATTGGTTATCGCCGTGGTAGCGGTAGGCAAA
CGTGAGCGTAGTGGCGTTTATCATCTGGCGAGTGAACGAATGAGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179256 WP_002916312.1 NZ_CP063896:3224053-3224319 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179256 NZ_CP084654:4925814-4926065 [Pectobacterium versatile]
ATGCCAAATATTATATTAAGCGATACCAGTGCCAGCGTCAGTGAACTGAAAAAGAACCCGATGGCGACGGTCAATGCTGG
TGATGGCCTGCCTGTCGCTATCTTGAACCGCAACCAACCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAGGAGCTGGTTAAGCTGATCGGTGAACGTAAAAACCAGCCGCTGGTTGACGTGGATTTGGAT
AGTTTCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References