Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 114876..115786 Replicon plasmid pBS433-2
Accession NZ_CP063891
Organism Klebsiella pneumoniae strain BS433-2

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag ISB10_RS26885 Protein ID WP_004026354.1
Coordinates 114876..115346 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag ISB10_RS26890 Protein ID WP_004026357.1
Coordinates 115343..115786 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB10_RS26845 109960..110562 - 603 WP_011251277.1 hypothetical protein -
ISB10_RS26850 110565..111080 - 516 WP_041937820.1 hypothetical protein -
ISB10_RS26855 111188..111763 - 576 WP_074424927.1 hypothetical protein -
ISB10_RS26860 111880..112836 - 957 WP_011251280.1 DsbA family protein -
ISB10_RS26865 112896..113237 - 342 WP_011251281.1 hypothetical protein -
ISB10_RS26870 113251..113562 - 312 WP_011251282.1 hypothetical protein -
ISB10_RS26875 113579..114013 - 435 Protein_121 thioredoxin fold domain-containing protein -
ISB10_RS26880 114030..114727 - 698 Protein_122 IS1 family transposase -
ISB10_RS26885 114876..115346 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
ISB10_RS26890 115343..115786 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
ISB10_RS26895 115887..116390 - 504 Protein_125 DUF4113 domain-containing protein -
ISB10_RS26900 116488..116709 - 222 WP_004213643.1 DUF2188 domain-containing protein -
ISB10_RS26905 116854..117009 - 156 WP_004213642.1 hypothetical protein -
ISB10_RS26910 117084..119210 - 2127 WP_004213640.1 TonB-dependent receptor family protein -
ISB10_RS26915 119297..120250 - 954 Protein_129 fec operon regulator FecR -
ISB10_RS26920 120247..120768 - 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA 1..227749 227749
- flank IS/Tn - - 114030..114533 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T179252 WP_004026354.1 NZ_CP063891:c115346-114876 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T179252 NZ_CP084654:c4569306-4568995 [Pectobacterium versatile]
ATGCATGTTATTTCGCGCGCACCTTTCGACACTGCAACCACTCAGTTTCCGAATCAGGCGGCAGCACTTGCTGATCTATA
TAGGGTGATCAAACGCGAAATGTATGCAACGCCGGACGATATGAAAAAACGCTTCCCCAGCCTGGATAGGATGAAATATC
GGGAAAAGTGGTGGGTTATTGATATTGGTGGCGGGCATCTTCGAGTGATGTTTTTTGCTGATTTCGAGCGGGGGAAAATC
TTCATCAAGCACATCACATCCCATGCAGAGTACGACAGGCTGACAGAGTATTACCGGAGGAATAAAGAATGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT179252 WP_004026357.1 NZ_CP063891:c115786-115343 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT179252 NZ_CP084654:c4568998-4568582 [Pectobacterium versatile]
ATGATGTACGCCGACGCCATCAAGGCAGCTAACAACCTGACGAGTATCGTACCATTCCTCGGAGGCAGCACCTCTCGTAA
GGATTATGAGGATGCACTGAAACTCACTGAATACCTGATCGAGAGTGAACCTGACAGTCCGCTAATCGATATGCTGACTG
CCAAAATTGACAAATACGAAGATGATGCACCGGAGTTTGCAGCCTTCAACGAACGTGTTAAAGCACTCCCAGCAGGTATC
GCTTTACTGCGCGTCCTTATGGATCAGCATCAGCTAACGCAGAGTGATTTTGAAGCTGAGATTGGTAAAAAGTCTCTGGT
ATCCCGCATTCTAAAAGGTGAGCGCACTCTAACGCTGGATCACATGAGAGCGCTTGCTAAACGATTCAATATTCCCGTGA
GTGCTTTTGTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References