Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5261019..5262607 Replicon chromosome
Accession NZ_CP063890
Organism Klebsiella pneumoniae strain BS433-2

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag ISB10_RS25260 Protein ID WP_014907613.1
Coordinates 5261285..5262607 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag ISB10_RS25255 Protein ID WP_002904790.1
Coordinates 5261019..5261285 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB10_RS25230 5256197..5257120 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
ISB10_RS25235 5257101..5258255 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
ISB10_RS25240 5258601..5259980 + 1380 WP_004184021.1 purine permease -
ISB10_RS25245 5259958..5260458 + 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ISB10_RS25250 5260455..5260781 + 327 WP_004215084.1 hydroxyisourate hydrolase -
ISB10_RS25255 5261019..5261285 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ISB10_RS25260 5261285..5262607 + 1323 WP_014907613.1 type II toxin-antitoxin system HipA family toxin Toxin
ISB10_RS25265 5262624..5263916 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
ISB10_RS25270 5264058..5265062 - 1005 WP_014907612.1 type 1 fimbrial protein -
ISB10_RS25275 5265050..5267551 - 2502 WP_014907611.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T179250 WP_014907613.1 NZ_CP063890:5261285-5262607 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T179250 NZ_CP084654:4465847-4466101 [Pectobacterium versatile]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTATCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAAGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTTGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGGTGACGCCATGATGATAGCCGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT179250 WP_002904790.1 NZ_CP063890:5261019-5261285 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT179250 NZ_CP084654:4465599-4465850 [Pectobacterium versatile]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCTAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTTATGTCTCTGGAAGAGTATAACTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331XLA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References