Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3133547..3134063 Replicon chromosome
Accession NZ_CP063890
Organism Klebsiella pneumoniae strain BS433-2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag ISB10_RS15175 Protein ID WP_004178374.1
Coordinates 3133779..3134063 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ISB10_RS15170 Protein ID WP_002886901.1
Coordinates 3133547..3133789 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB10_RS15155 3129575..3130315 + 741 WP_002886899.1 KDGP aldolase family protein -
ISB10_RS15160 3130382..3131536 + 1155 WP_012737230.1 lactonase family protein -
ISB10_RS15165 3131559..3133469 + 1911 WP_012737231.1 BglG family transcription antiterminator -
ISB10_RS15170 3133547..3133789 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISB10_RS15175 3133779..3134063 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISB10_RS15180 3134067..3134531 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISB10_RS15185 3134860..3136998 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
ISB10_RS15190 3137355..3138098 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ISB10_RS15195 3138101..3138274 - 174 WP_041169004.1 hypothetical protein -
ISB10_RS15200 3138359..3138667 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T179247 WP_004178374.1 NZ_CP063890:3133779-3134063 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T179247 NZ_CP084654:c4224874-4224461 [Pectobacterium versatile]
GTGGCCCAGTGGCGATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTGGTGCATGGCCTCTTAGTATT
ATTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAAAGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAAATCGTTAAACGACCGTGGCTGCTGAAGAATGGCGTGTTGCTGTCATTGCAGGCGGTTAACGCTAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCACTTGCGTCAGCTTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179247 WP_002886901.1 NZ_CP063890:3133547-3133789 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179247 NZ_CP084654:c4225121-4224855 [Pectobacterium versatile]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACACTGATAAGCGTACGTTTGTACGTTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGAAGGACGGAGAGCTGAAACGCATGATTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References