Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1788434..1789091 Replicon chromosome
Accession NZ_CP063890
Organism Klebsiella pneumoniae strain BS433-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISB10_RS08615 Protein ID WP_002916310.1
Coordinates 1788434..1788844 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISB10_RS08620 Protein ID WP_002916312.1
Coordinates 1788825..1789091 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB10_RS08595 1784434..1786167 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
ISB10_RS08600 1786173..1786886 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISB10_RS08605 1786909..1787805 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISB10_RS08610 1787906..1788427 + 522 WP_002916308.1 flavodoxin FldB -
ISB10_RS08615 1788434..1788844 - 411 WP_002916310.1 protein YgfX Toxin
ISB10_RS08620 1788825..1789091 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISB10_RS08625 1789337..1790320 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
ISB10_RS08630 1790419..1791078 - 660 WP_002916317.1 hemolysin III family protein -
ISB10_RS08635 1791242..1791553 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISB10_RS08640 1791603..1792331 + 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
ISB10_RS08645 1792450..1793883 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179243 WP_002916310.1 NZ_CP063890:c1788844-1788434 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179243 NZ_CP084654:3942702-3943007 [Pectobacterium versatile]
ATGCAATTCATTGTTTATCAATACAAACGCGCCAGTCACTACACAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCCAAGCGGCGCATGGTCATCCCGCTTATCGAATCACATCACCTGTCTGCGAAAGTGAATAAGACTTTGTTCCCTCTGA
TCCGCATCGACGGCGAAGAGTATCGGTTGATGACGACTGAGCTATCGAGCGTTCCCGTGGAGGTTATTGGTGAAGTGATT
GCGGATCTCAGCGACTGTGCGGATGAGATCAAGGGTGCTCTTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179243 WP_002916312.1 NZ_CP063890:c1789091-1788825 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179243 NZ_CP084654:3942481-3942699 [Pectobacterium versatile]
ATGAAACACCGCGTCAGCGTTACCGTAGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAATCAATATCTCTGGGCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGCATCAAGGCTGAGGAGTGGAAGAAAGAAAACCGCGAAGGGATGGAGG
AAGTCGCCCGATTTATCGCACAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References