Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 1788434..1789091 | Replicon | chromosome |
Accession | NZ_CP063890 | ||
Organism | Klebsiella pneumoniae strain BS433-2 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | W8UCT0 |
Locus tag | ISB10_RS08615 | Protein ID | WP_002916310.1 |
Coordinates | 1788434..1788844 (-) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | ISB10_RS08620 | Protein ID | WP_002916312.1 |
Coordinates | 1788825..1789091 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ISB10_RS08595 | 1784434..1786167 | - | 1734 | WP_004149758.1 | single-stranded-DNA-specific exonuclease RecJ | - |
ISB10_RS08600 | 1786173..1786886 | - | 714 | WP_002916301.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
ISB10_RS08605 | 1786909..1787805 | - | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
ISB10_RS08610 | 1787906..1788427 | + | 522 | WP_002916308.1 | flavodoxin FldB | - |
ISB10_RS08615 | 1788434..1788844 | - | 411 | WP_002916310.1 | protein YgfX | Toxin |
ISB10_RS08620 | 1788825..1789091 | - | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
ISB10_RS08625 | 1789337..1790320 | + | 984 | WP_014906951.1 | tRNA-modifying protein YgfZ | - |
ISB10_RS08630 | 1790419..1791078 | - | 660 | WP_002916317.1 | hemolysin III family protein | - |
ISB10_RS08635 | 1791242..1791553 | - | 312 | WP_004144734.1 | N(4)-acetylcytidine aminohydrolase | - |
ISB10_RS08640 | 1791603..1792331 | + | 729 | WP_048336809.1 | MurR/RpiR family transcriptional regulator | - |
ISB10_RS08645 | 1792450..1793883 | + | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16049.85 Da Isoelectric Point: 11.4778
>T179243 WP_002916310.1 NZ_CP063890:c1788844-1788434 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T179243 NZ_CP084654:3942702-3943007 [Pectobacterium versatile]
ATGCAATTCATTGTTTATCAATACAAACGCGCCAGTCACTACACAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCCAAGCGGCGCATGGTCATCCCGCTTATCGAATCACATCACCTGTCTGCGAAAGTGAATAAGACTTTGTTCCCTCTGA
TCCGCATCGACGGCGAAGAGTATCGGTTGATGACGACTGAGCTATCGAGCGTTCCCGTGGAGGTTATTGGTGAAGTGATT
GCGGATCTCAGCGACTGTGCGGATGAGATCAAGGGTGCTCTTAATCTTATGTTTTGGGGGATTTGA
ATGCAATTCATTGTTTATCAATACAAACGCGCCAGTCACTACACAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCCAAGCGGCGCATGGTCATCCCGCTTATCGAATCACATCACCTGTCTGCGAAAGTGAATAAGACTTTGTTCCCTCTGA
TCCGCATCGACGGCGAAGAGTATCGGTTGATGACGACTGAGCTATCGAGCGTTCCCGTGGAGGTTATTGGTGAAGTGATT
GCGGATCTCAGCGACTGTGCGGATGAGATCAAGGGTGCTCTTAATCTTATGTTTTGGGGGATTTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT179243 WP_002916312.1 NZ_CP063890:c1789091-1788825 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT179243 NZ_CP084654:3942481-3942699 [Pectobacterium versatile]
ATGAAACACCGCGTCAGCGTTACCGTAGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAATCAATATCTCTGGGCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGCATCAAGGCTGAGGAGTGGAAGAAAGAAAACCGCGAAGGGATGGAGG
AAGTCGCCCGATTTATCGCACAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA
ATGAAACACCGCGTCAGCGTTACCGTAGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAATCAATATCTCTGGGCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGCATCAAGGCTGAGGAGTGGAAGAAAGAAAACCGCGAAGGGATGGAGG
AAGTCGCCCGATTTATCGCACAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GSW7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |