Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3217526..3218183 Replicon chromosome
Accession NZ_CP063887
Organism Klebsiella quasipneumoniae strain BM419-3

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag ISB14_RS15590 Protein ID WP_004205323.1
Coordinates 3217773..3218183 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISB14_RS15585 Protein ID WP_002916312.1
Coordinates 3217526..3217792 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB14_RS15560 3212735..3214168 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
ISB14_RS15565 3214287..3215015 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
ISB14_RS15570 3215065..3215376 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
ISB14_RS15575 3215539..3216198 + 660 WP_004205319.1 hemolysin III family protein -
ISB14_RS15580 3216297..3217280 - 984 WP_122542307.1 tRNA-modifying protein YgfZ -
ISB14_RS15585 3217526..3217792 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISB14_RS15590 3217773..3218183 + 411 WP_004205323.1 protein YgfX Toxin
ISB14_RS15595 3218190..3218711 - 522 WP_004205324.1 flavodoxin FldB -
ISB14_RS15600 3218812..3219708 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISB14_RS15605 3219731..3220444 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISB14_RS15610 3220450..3222183 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T179207 WP_004205323.1 NZ_CP063887:3217773-3218183 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179207 NZ_CP084647:c2021235-2021142 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179207 WP_002916312.1 NZ_CP063887:3217526-3217792 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179207 NZ_CP084647:2021138-2021284 [Yersinia ruckeri]
AGTTAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References