Detailed information of TA system TA179206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1856577..1857090
• Replicon: chromosome
• Accession: NZ_CP063887
• Organism: Klebsiella quasipneumoniae strain BM419-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A663BE04
• Locus tag: ISB14_RS08950
• Protein ID: WP_017900571.1
• Coordinates: 1856577..1856858 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ISB14_RS08955
• Protein ID: WP_048322784.1
• Coordinates: 1856848..1857090 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISB14_RS08940	1853588..1855726	+	2139	WP_080838453.1	anaerobic ribonucleoside-triphosphate reductase	-
ISB14_RS08945	1856109..1856573	+	465	WP_023319597.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
ISB14_RS08950	1856577..1856858	-	282	WP_017900571.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ISB14_RS08955	1856848..1857090	-	243	WP_048322784.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ISB14_RS08960	1857168..1859078	-	1911	WP_004206509.1	BglG family transcription antiterminator	-
ISB14_RS08965	1859101..1860255	-	1155	WP_065697356.1	lactonase family protein	-
ISB14_RS08970	1860418..1861158	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11082.93 Da
• Isoelectric Point: 10.4123

>T179206 WP_017900571.1 NZ_CP063887:c1856858-1856577 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T179206 NZ_CP084647:1882727-1883185 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9117.61 Da
• Isoelectric Point: 5.1486

>AT179206 WP_048322784.1 NZ_CP063887:c1857090-1856848 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT179206 NZ_CP084647:1882267-1882713 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGCATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATATCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Structures

Toxin

• AlphaFold DB: A0A663BE04