Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1142295..1142914 Replicon chromosome
Accession NZ_CP063887
Organism Klebsiella quasipneumoniae strain BM419-3

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISB14_RS05630 Protein ID WP_002892050.1
Coordinates 1142696..1142914 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISB14_RS05625 Protein ID WP_002892066.1
Coordinates 1142295..1142669 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB14_RS05615 1137448..1138641 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ISB14_RS05620 1138664..1141810 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
ISB14_RS05625 1142295..1142669 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISB14_RS05630 1142696..1142914 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISB14_RS05635 1143073..1143639 + 567 WP_004204750.1 maltose O-acetyltransferase -
ISB14_RS05640 1143611..1143733 - 123 WP_032426076.1 hypothetical protein -
ISB14_RS05645 1143776..1144246 + 471 WP_004204751.1 YlaC family protein -
ISB14_RS05650 1144215..1145672 - 1458 WP_064178013.1 PLP-dependent aminotransferase family protein -
ISB14_RS05655 1145773..1146471 + 699 WP_004204753.1 GNAT family N-acetyltransferase -
ISB14_RS05660 1146468..1146608 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISB14_RS05665 1146608..1146871 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179205 WP_002892050.1 NZ_CP063887:1142696-1142914 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179205 NZ_CP084647:c949035-948832 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179205 WP_002892066.1 NZ_CP063887:1142295-1142669 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179205 NZ_CP084647:c949455-949087 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References