Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3145500..3146119 Replicon chromosome
Accession NZ_CP063885
Organism Klebsiella pneumoniae strain BS361-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISB15_RS15140 Protein ID WP_002892050.1
Coordinates 3145500..3145718 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISB15_RS15145 Protein ID WP_002892066.1
Coordinates 3145745..3146119 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB15_RS15105 3141547..3141810 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
ISB15_RS15110 3141810..3141950 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISB15_RS15115 3141947..3142645 - 699 WP_004177238.1 GNAT family N-acetyltransferase -
ISB15_RS15120 3142746..3144197 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
ISB15_RS15125 3144172..3144642 - 471 WP_002892026.1 YlaC family protein -
ISB15_RS15130 3144663..3144803 + 141 WP_004147370.1 hypothetical protein -
ISB15_RS15135 3144775..3145341 - 567 WP_002892030.1 maltose O-acetyltransferase -
ISB15_RS15140 3145500..3145718 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISB15_RS15145 3145745..3146119 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISB15_RS15150 3146605..3149751 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
ISB15_RS15155 3149774..3150967 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179193 WP_002892050.1 NZ_CP063885:c3145718-3145500 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179193 NZ_CP084643:c958752-958549 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179193 WP_002892066.1 NZ_CP063885:c3146119-3145745 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179193 NZ_CP084643:c959172-958804 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References