Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2438464..2438980 Replicon chromosome
Accession NZ_CP063885
Organism Klebsiella pneumoniae strain BS361-1

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag ISB15_RS11765 Protein ID WP_009309309.1
Coordinates 2438696..2438980 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ISB15_RS11760 Protein ID WP_002886901.1
Coordinates 2438464..2438706 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB15_RS11745 2434492..2435232 + 741 WP_002886899.1 KDGP aldolase family protein -
ISB15_RS11750 2435299..2436453 + 1155 WP_194429444.1 lactonase family protein -
ISB15_RS11755 2436476..2438386 + 1911 WP_009486549.1 BglG family transcription antiterminator -
ISB15_RS11760 2438464..2438706 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISB15_RS11765 2438696..2438980 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISB15_RS11770 2438984..2439448 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISB15_RS11775 2439697..2441835 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
ISB15_RS11780 2442192..2442935 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ISB15_RS11785 2442938..2443111 - 174 WP_032408826.1 hypothetical protein -
ISB15_RS11790 2443196..2443504 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T179190 WP_009309309.1 NZ_CP063885:2438696-2438980 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T179190 NZ_CP084643:463863-464153 [Yersinia ruckeri]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAACTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGTTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTGGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATATTGCCAAGAAGCGAATCCAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179190 WP_002886901.1 NZ_CP063885:2438464-2438706 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179190 NZ_CP084643:463619-463873 [Yersinia ruckeri]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGCCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCTTTTTCAGAAGTATCCGTAATGGTCA
GTAATCAAGATGTGGATGCTGATATTTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCAAAGCGTATCAGAGTAAAT
ATTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References