Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1100758..1101415 Replicon chromosome
Accession NZ_CP063885
Organism Klebsiella pneumoniae strain BS361-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISB15_RS05240 Protein ID WP_002916310.1
Coordinates 1100758..1101168 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISB15_RS05245 Protein ID WP_002916312.1
Coordinates 1101149..1101415 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB15_RS05220 1096758..1098491 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
ISB15_RS05225 1098497..1099210 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISB15_RS05230 1099233..1100129 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISB15_RS05235 1100230..1100751 + 522 WP_004144730.1 flavodoxin FldB -
ISB15_RS05240 1100758..1101168 - 411 WP_002916310.1 protein YgfX Toxin
ISB15_RS05245 1101149..1101415 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISB15_RS05250 1101661..1102644 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ISB15_RS05255 1102795..1103454 - 660 WP_002916317.1 hemolysin III family protein -
ISB15_RS05260 1103618..1103929 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISB15_RS05265 1103979..1104707 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISB15_RS05270 1104826..1106259 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179185 WP_002916310.1 NZ_CP063885:c1101168-1100758 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179185 NZ_CP084642:c1710911-1710453 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGGTGGCGAGATGACCCCACCCCCGTGGCTACCATGGACATCGGCACCGAATGGATTGGTTCAGCATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179185 WP_002916312.1 NZ_CP063885:c1101415-1101149 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179185 NZ_CP084642:c1711371-1710925 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGTATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References