Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3335575..3336232 Replicon chromosome
Accession NZ_CP063881
Organism Klebsiella pneumoniae strain S90-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IOD49_RS16385 Protein ID WP_002916310.1
Coordinates 3335822..3336232 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IOD49_RS16380 Protein ID WP_002916312.1
Coordinates 3335575..3335841 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD49_RS16355 3330731..3332164 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IOD49_RS16360 3332283..3333011 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IOD49_RS16365 3333061..3333372 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
IOD49_RS16370 3333536..3334195 + 660 WP_002916317.1 hemolysin III family protein -
IOD49_RS16375 3334346..3335329 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IOD49_RS16380 3335575..3335841 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IOD49_RS16385 3335822..3336232 + 411 WP_002916310.1 protein YgfX Toxin
IOD49_RS16390 3336239..3336760 - 522 WP_002916308.1 flavodoxin FldB -
IOD49_RS16395 3336861..3337757 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IOD49_RS16400 3337780..3338493 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IOD49_RS16405 3338499..3340232 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179170 WP_002916310.1 NZ_CP063881:3335822-3336232 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179170 NZ_CP084639:1062378-1062698 [Yersinia ruckeri]
ATGCAAACTTTACCCGTATCTCCGACGCGGGAGGCTCAGCTTGGCCCGTCACCCGCAGCTGTCTGGAAACAACTCCTGAC
GCATCTGTTTGAGCACCATTACGGCCTGACGCTCAATGACACTCCCTTCTGCTACGAATTCGTAATACAGGAACATATTG
AATCCGGCATTTTGCTGAAAGATGCCGTGAATTTTGTGGTCGAACGCTATGGCCTTTTACGTATTGATCGCAGTAGTTTC
TCCTTTGATGAGCCGTCACCGTTTATTAATTTTACCGATATTCTTCGAGCCAGACGAGCAATCGGACTGATGAATACTTA
A

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179170 WP_002916312.1 NZ_CP063881:3335575-3335841 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179170 NZ_CP084639:1061935-1062303 [Yersinia ruckeri]
ATGAAACCTACTCCATCCAAAACTATCCCACCGAAGGACACTACCGCCTGTCTGCAATGGGGGCTTCGGCACGACATCAC
GCCGTGTTTTGGCGCAAGACTGGTACAGGAAGGCCAACGCCTGCATTTTCTGGCTGATCGTGCTGGTTTTTGCGGTGTAT
TCAGCGAGGAAGGGGCCCGACATCTGGATCAGGCTTTCCCACTAATAATGAAACAACTGGAACTGGCATTACTCTCCGGT
GAGCTTGATCCTCGCTACCAGCGGAGCATCACGCTGAGCCACAATGGCCTGACCTGCGAAGCCGACGCCCTCGGGTCGCA
CGGCTACGTCTACATCACTATTTATCCGACACCTTCAGTAACGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References