Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1808285..1809120 Replicon chromosome
Accession NZ_CP063881
Organism Klebsiella pneumoniae strain S90-2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag IOD49_RS08905 Protein ID WP_001559913.1
Coordinates 1808285..1808662 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag IOD49_RS08910 Protein ID WP_032408847.1
Coordinates 1808752..1809120 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD49_RS08865 1803549..1803815 + 267 WP_004178415.1 hypothetical protein -
IOD49_RS08870 1803815..1804487 + 673 Protein_1738 DUF4400 domain-containing protein -
IOD49_RS08875 1804498..1805382 + 885 WP_102001089.1 RES domain-containing protein -
IOD49_RS08880 1805581..1805769 - 189 Protein_1740 transposase -
IOD49_RS08885 1805786..1806897 - 1112 Protein_1741 IS3 family transposase -
IOD49_RS08890 1807346..1807498 - 153 WP_164713811.1 hypothetical protein -
IOD49_RS08895 1807583..1807780 - 198 WP_032408848.1 DUF957 domain-containing protein -
IOD49_RS08900 1807800..1808288 - 489 WP_001559914.1 hypothetical protein -
IOD49_RS08905 1808285..1808662 - 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
IOD49_RS08910 1808752..1809120 - 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IOD49_RS08915 1809297..1809518 - 222 WP_000692300.1 DUF987 domain-containing protein -
IOD49_RS08920 1809587..1810063 - 477 WP_032408846.1 RadC family protein -
IOD49_RS08925 1810078..1810563 - 486 WP_088607457.1 antirestriction protein -
IOD49_RS08930 1810655..1811473 - 819 WP_001559911.1 DUF945 domain-containing protein -
IOD49_RS08935 1811573..1811806 - 234 WP_001119729.1 DUF905 family protein -
IOD49_RS08940 1811885..1812340 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1797666..1829537 31871


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T179162 WP_001559913.1 NZ_CP063881:c1808662-1808285 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T179162 NZ_CP084635:c2098683-2098590 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT179162 WP_032408847.1 NZ_CP063881:c1809120-1808752 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT179162 NZ_CP084635:2098586-2098732 [Yersinia ruckeri]
AGTTAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References