Detailed information of TA system TA179155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4174647..4176235
• Replicon: chromosome
• Accession: NZ_CP063878
• Organism: Klebsiella pneumoniae strain M169-3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: ISB47_RS20745
• Protein ID: WP_004184027.1
• Coordinates: 4174647..4175969 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: ISB47_RS20750
• Protein ID: WP_004176198.1
• Coordinates: 4175969..4176235 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISB47_RS20730 (4169703)	4169703..4172204	+	2502	WP_117051210.1	fimbria/pilus outer membrane usher protein	-
ISB47_RS20735 (4172192)	4172192..4173196	+	1005	WP_016946380.1	fimbrial protein	-
ISB47_RS20740 (4173338)	4173338..4174630	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
ISB47_RS20745 (4174647)	4174647..4175969	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
ISB47_RS20750 (4175969)	4175969..4176235	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
ISB47_RS20755 (4176501)	4176501..4176827	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
ISB47_RS20760 (4176824)	4176824..4177324	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
ISB47_RS20765 (4177302)	4177302..4178681	-	1380	WP_032418979.1	nucleobase:cation symporter-2 family protein	-
ISB47_RS20770 (4179027)	4179027..4180181	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
ISB47_RS20775 (4180162)	4180162..4181085	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T179155 WP_004184027.1 NZ_CP063878:c4175969-4174647 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T179155 NZ_CP084594:26435-26755 [Mycobacterium intracellulare subsp. chimaera]
GTGAACCGCGGCGAGCTATGGACCGTCTCGGGGGGCGTCTATGCCGCCAAACCTCGTCCGGCGCTCATCATCCAGGACAA
CCTGTTCTCCGCAACGGAATCGGTCGTCGTCATCCCGCTGACCACGACGATCGCTGACGCGCCGATAGCGCGAATCGCAG
TACCAACCACCACCGGAATTGCCCAGCCCAGCTTCGCCATGATCGACAAGATCACCACAGTCCGCCGGTCGAACCTCGGG
ACGCGGGTCGGTCGTGTGTCCGCCACGCTTATGGCCGACATCGAACGATCGCTCATGGTATTCCTCGGCCTTGCCTCCTG
A

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT179155 WP_004176198.1 NZ_CP063878:c4176235-4175969 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT179155 NZ_CP084594:26271-26438 [Mycobacterium intracellulare subsp. chimaera]
ATGCGCGAACGCGGGTACCGCCCGGTCCAAGTGTGGGTGCCTGACGTCCGGTCAGCGCGGTTTGCCGCAGAAGCACACCG
GGAAGCACTGGCGCTGGCCGAAGCCGACCGACACAGCGATGACATGGACTTCGTCGAGGCGATCTCCGACCTGGTCGATA
ACGAGTGA