Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2206716..2207373 Replicon chromosome
Accession NZ_CP063878
Organism Klebsiella pneumoniae strain M169-3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISB47_RS10935 Protein ID WP_002916310.1
Coordinates 2206963..2207373 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISB47_RS10930 Protein ID WP_002916312.1
Coordinates 2206716..2206982 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB47_RS10905 (2201872) 2201872..2203305 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
ISB47_RS10910 (2203424) 2203424..2204152 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISB47_RS10915 (2204202) 2204202..2204513 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ISB47_RS10920 (2204677) 2204677..2205336 + 660 WP_002916317.1 hemolysin III family protein -
ISB47_RS10925 (2205487) 2205487..2206470 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ISB47_RS10930 (2206716) 2206716..2206982 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISB47_RS10935 (2206963) 2206963..2207373 + 411 WP_002916310.1 protein YgfX Toxin
ISB47_RS10940 (2207380) 2207380..2207901 - 522 WP_004144730.1 flavodoxin FldB -
ISB47_RS10945 (2208002) 2208002..2208898 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISB47_RS10950 (2208921) 2208921..2209634 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISB47_RS10955 (2209640) 2209640..2211373 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179145 WP_002916310.1 NZ_CP063878:2206963-2207373 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179145 NZ_CP084592:1601857-1602225 [Mycobacterium intracellulare subsp. chimaera]
ATGATCCTCGTCGACACCGCGGTGTGGATCGATCATCTACACACCGCGGAGTTGCGGCTAGTCAAGCTGCTGGAGATCGA
CCAAGTTGGCTGTCATGCGCTGGTCATCGAAGAGCTGGCGCTGGGGTCGATCTCGCGACGTGAGGTGGTGCTCGACCTCC
TCGCGAATCTTCGCCAGTTTCCGACCGTCCAGCACGCCGAGATCCTTCACCTCACCGGTCAACGCAAACTGTATGGACGC
GGTCTCAGTGCGGTCGACGTCCATCTCATGGCCGCCGTCGCCCTGGTTGAAGGCGCGCAGCTGTGGACGAGAGACAAGCG
GTTGAAGGCTGCGTCGGTCGATGCGGGCATCGCACTCTTCGATGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179145 WP_002916312.1 NZ_CP063878:2206716-2206982 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179145 NZ_CP084592:1601663-1601860 [Mycobacterium intracellulare subsp. chimaera]
ATGCGGACCACAGTCACGATCGACGACGACCTGTTGGCCAAGGCTGCTGAGTTGACCGGCGTGCGCGAGAACGTCGCGTT
GCTCCGCGAGGGATTGCAGACGCTGATCAGGGTGGAAAGCGCTCGCCGACTTGCCGCGCTCGGCGGGACGGATGCCGGGG
CGGTGGCCGCTCCCCGGCGCCGCCGTGGGACTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References